plasma free hemoglobin

Plasma free hemoglobin refers to the determination of the amount of hemoglobin in plasma. Under normal circumstances, the red blood cell life is 120 days, the aging red blood cells are destroyed in the spleen, decomposed into hemoglobin, and then gradually degraded into iron, globin, bilirubin. Usually hemoglobin is present in red blood cells. When red blood cells are destroyed, such as hemolysis, hemoglobin is released into the blood, and free hemoglobin in the plasma is increased. Determination of plasma free hemoglobin can reflect the destruction of red blood cells in the blood of patients with hemolytic anemia. Basic Information Specialist classification: Infectious disease examination and classification: blood examination Applicable gender: whether men and women apply fasting: fasting Tips: It is generally required to draw blood in the morning, try to reduce the amount of exercise before taking blood, do not eat food, keep fasting. Normal value The peroxidase-like reaction method is <40 mg/L (<4 mg/dl). Clinical significance (1) elevated hemolytic anemia (60 ~ 650mg / L), paroxysmal nocturnal hemoglobinuria (200 ~ 2500mg / L), paroxysmal cold hemoglobinuria, paroxysmal marching hemoglobinuria, Black urine fever, cold agglutinin disease, burns, hemolytic transfusion reaction (>150mg/L), after cardiopulmonary bypass surgery, warm antibody-type autoimmune hemolytic anemia, sickle cell anemia, thalassemia and so on. (2) The free hemoglobin concentration of hereditary spherocytic anemia is normal. Precautions 1. Follow the precautions for blood tests, such as fasting. 2, extravascular hemolysis (such as hereditary spherocytosis), plasma free hemoglobin is normal. Inspection process It is determined by the same type of peroxidase reaction method. Not suitable for the crowd No taboos. Adverse reactions and risks Subcutaneous hemorrhage: subcutaneous hemorrhage due to less than 5 minutes of compression time or blood draw technique.

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