sickle cell

The shape of the sickle cell is like a sickle. This is due to the abnormal hemoglobin S in the red blood cells. The human body easily forms such red blood cells in the absence of oxygen. Therefore, examination of the sickle-shaped red blood cells requires the blood to be made into a wet sheet, and then a reducing agent such as sodium metabisulfite is added. Basic Information Specialist classification: cardiovascular examination classification: blood examination Applicable gender: whether men and women apply fasting: fasting Analysis results: Below normal: Normal value: no Above normal: negative: normal. Positive: Hereditary sickle polycythemia. Tips: Keep a normal mindset. Normal value None (negative). Clinical significance Abnormal result Positive hereditary sickle polycythemia. Sickle cell disease, also known as sickle cell anemia, is a hereditary disease that causes the patient's red blood cells to flatten or distort, changing the shape of the red blood cells into a sickle-like shape. In this way, red blood cells are destroyed and oxygen cannot be carried to various parts of the body. In addition, the red blood cells tend to stick together to form clots, causing heart disease or stroke. Hypoxia and the formation of clots can also cause severe pain in the legs, arms, chest, back, etc. Positive result may be disease: encephalopathy precautions Inappropriate people: generally no special population. Pre-inspection contraindications: Red blood cell count decreased from 5 pm to 7 am and after meals, up to 10%, bed rest can be reduced by 5.7% compared with normal activities, so should be considered when evaluating two blood test results Factors such as time, diet and bed rest. Requirements for inspection: Red blood cell count is highly prone to errors. Venous blood collection, long-term ligation of the tourniquet can cause false increase, the pipette is unclean, not accurate, will count or increase or decrease; draw the diluent, now use a manual dosing device, the capacity should be calibrated before use; Try to buy the exact one; count enough when counting. If you pay attention to it, the results obtained by the manual method still have good accuracy and can be used to correct the automatic counter. Inspection process Since the anti-sputum gene is very large, it is difficult to introduce into bone marrow cells. Even if introduced, the expression level is usually very low, and it is often inactivated in bone marrow stem cells. In order to overcome these technical obstacles, they used various new discoveries and new methods, selected the best alternative genes, and constructed an efficient vector expression system. Not suitable for the crowd Generally no taboos. Adverse reactions and risks Generally not.

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