Vitamin B6

Vitamin B6 mainly includes pyridoxine, pyridoxal and pyridoxamine. Pyridoxine is rapidly converted into pyridoxal in the liver, which constitutes the bioenzyme 5'-phosphate pyridoxal and 5'-pyridylamine. . In order to assess the nutritional status of vitamin B6, to determine the effect of supplementation, or to monitor the course of a disease that alters the nutritional status of vitamin B6, it is recommended to measure pyridoxal 5'-phosphate in plasma. Basic Information Specialist classification: growth and development check classification: biochemical examination Applicable gender: whether men and women apply fasting: fasting Tips: Do not eat too greasy, high-protein foods the day before the blood draw, avoid heavy drinking. Normal value Healthy adult male: 53nmol/L; Healthy adult female: 30nmol/L. Clinical significance Abnormal results: 1. It is generally considered that the two values ​​listed in the reference range define the nutritional status of vitamin B6 to be barely qualified and normal. When the concentration of pyridoxal 5'-phosphate in plasma is less than 15 nmol/L, vitamin B6 deficiency should be suspected. 2. The concentration of pyridoxal 5'-phosphate in serum may decrease slightly with age, but the normal range of age dependence has not been determined. 3. Pregnancy and breastfeeding will reduce the concentration of pyridoxal 5'-phosphate in serum. Does this reflect the lack of vitamin B6, or it is still unclear about the normal physiological phenomena associated with pregnancy and breastfeeding. 4, the vitamin B6 deficiency deficiency seen in the clinic is caused by taking vitamin B6 antagonists, and a few are seen in malignant tumors, severe liver diseases, severe kidney disease, and chronic alcoholism. Insufficient or lacking of vitamin B6 can also occur in infants or the elderly due to unreasonable diet. The use or overdose of the following drugs may result in the lack of VitB6, such as isoniazid, amitriptyline and the like. Low results may be diseases: folic acid deficiency in children, vitamin D deficiency in children, hand and foot rickets, vitamin B2 deficiency in children, infantile hand and foot sputum, neonatal intracranial hemorrhage, neonatal seizures, nutritional deficiency neuropathy, lack of nutritional metabolism, Precautions for senile depression 1. Please inform the doctor about the recent medication and special physiological changes before the test. 2, do not eat too greasy, high-protein food the day before the blood, to avoid heavy drinking. The alcohol content in the blood directly affects the test results. 3. After 8 pm on the day before the medical examination, you should start fasting for 12 hours to avoid affecting the test results. 4, the requirements of the examination: should relax when taking blood, to avoid the contraction of blood vessels caused by fear, increase the difficulty of blood collection. 5, serum and plasma are available, fasting overnight, early morning blood collection. When plasma is used, it is anticoagulated with EDTA, heparin or sodium citrate. It does not interfere with the measurement results. 6. If it is measured on the improper day after sampling, the sample can be placed in the Ep tube, sealed and sealed, and stored at -20 °C in the dark. The annual loss of 5'-pyridoxal phosphate is less than 1%. Each time the sample freezes and thaws, it can cause a loss of about 5% of pyridoxal 5'-phosphate. Inspection process The venous blood samples were taken immediately and sent for examination, and detected by tyrosine deamination decarboxylase method. Other indicators can be used to determine the nutritional status of vitamin B6. These indicators include the excretion of vitamin B6 in 24 hours of urine, and the excretion of 4-pyruic acid, an important metabolite of vitamin B6 in 24 hours of urine. There are also two functional assays that can be used to evaluate vitamin B6 nutritional status: One method is to measure the various metabolites of tryptophan excreted in the urine for 24 hours after oral administration of 2 to 5 g of L-tryptophan. This method can indirectly indicate whether the vitamin B6 content in the liver is appropriate. Another method is to measure aspartate aminotransferase or alanine aminotransferase activity in red blood cells or serum. However, the most sensitive indicator of the best correlation with the nutritional status of vitamin B6 is plasma pyridoxal 5'-phosphate. Not suitable for the crowd Need to check the population's nutritional status is not good. Those without vitamin deficiency do not need to be examined. Adverse reactions and risks Vitamin B6 is a kind of B vitamins, also known as anti-dermatitis vitamins. It is widely distributed in food and closely related to amino acid metabolism. It is a coenzyme of decarboxylase. This is a water-soluble vitamin that is easily lost during cooking. Vitamin B6 mainly acts on the blood, muscles, nerves, skin, etc. of the human body. The functions include the synthesis of antibodies, the production of gastric acid in the digestive system, the utilization of fats and proteins (especially when supplementing weight loss), and the maintenance of sodium/potassium balance (stabilizing the nervous system). Symptoms of vitamin B6 deficiency in animals include dermatitis, sputum, anemia, and the like. Simple vitamin B6 deficiency is rare in humans. Symptoms of vitamin B6 deficiency: 1, the lack of vitamin B6 common symptoms, generally lack of loss of appetite, low food utilization, weight loss, vomiting, diarrhea and other problems. 2, a serious lack of acne, anemia, arthritis, child moles, depression, headache, hair loss, easy to inflammation, learning disabilities, weakness.

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