ceruloplasmin

Ceruloplasmin, also known as copper oxidase, is a copper-containing α2-glycoprotein with a molecular weight of approximately 150 kD and an electrophoretic position between α1 and α2-globulin (generally classified as α2 globulin). One molecule of ceruloplasmin binds to eight copper atoms, and about 90% of the copper atoms in the serum bind to ceruloplasmin. It is generally believed that ceruloplasmin is synthesized by the liver, and part of it is excreted by the biliary tract, and the amount of urine is very small. Basic Information Specialist classification: growth and development check classification: biochemical examination Applicable gender: whether men and women apply fasting: fasting Analysis results: Below normal: Hepatolenticular degeneration. Other severe infections, increased anemia; pregnancy, oral estrogen or some contraceptives, can also increase in biliary obstruction. Normal value: Ceruloplasmin: 0.21-0.53g/L Above normal: The probability of serum ceruloplasmin being higher than normal in primary liver cancer was >8.3%, and the probability of higher than normal in cirrhosis was 12.6%. Nephrotic syndrome and malnutrition are often reduced. negative: Positive: Tips: oral contraceptives and late pregnancy can increase the determination of ceruloplasmin. Normal value 0.21 ~ 0.53g / L, the newborn is higher, to 14 years old to normal levels. Clinical significance 1. The ceruloplasmin is significantly reduced in the diagnosis of hepatolenticular degeneration, which may be caused by excessive deposition of copper in the liver and basal ganglia or chloroblue protein synthesis. 2. There is no consensus on the changes of ceruloplasmin in chronic hepatitis and cirrhosis. In theory, the blood concentration should be reduced when hepatocytes are damaged, but 54 cases of chronic active liver disease patients with serum ceruloplasmin measured by RUSSO None of them decreased, but nearly half of them increased, which is quite different from hepatolenticular degeneration. 3. It is helpful to identify cirrhosis and liver cancer. The probability of serum ceruloplasmin being higher than normal in primary liver cancer is >8.3%, and the probability of higher than normal in cirrhosis is 12.6%. 4, other severe infections, anemia increased; pregnancy, oral estrogen or some contraceptives, biliary obstruction can also increase; nephrotic syndrome and malnutrition often decrease. The result is low, the disease may be high: the result of pediatric hepatolenticular degeneration may be high. Possible diseases: cirrhosis, primary liver cancer Oral contraceptives and late pregnancy can increase ceruloplasmin measurements. Inspection process Same as immunodiffusion assay. Not suitable for the crowd no. Adverse reactions and risks no.

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