Blood urea nitrogen to creatinine ratio

Scr and BUN can reflect the degree of damage of glomerular filtration function to a certain extent. BUN is also affected by extra-renal factors, such as high protein diet, gastrointestinal bleeding, dehydration and high catabolism, which can lead to increased BUN. In the case of stable intake of exogenous creatinine and constant production of creatinine in the body, Scr is mainly determined by the glomerular filtration capacity, so it is more accurate than BUN. Therefore, the observation of the ratio of serum urea nitrogen to creatinine has certain clinical significance. Basic Information Specialist classification: urinary examination classification: blood examination Applicable gender: whether men and women apply fasting: fasting Analysis results: Below normal: 1. Hunger, low protein diet. 2, combined with severe liver failure. 3. Diuretic. 4. Dialysis. Normal value: Blood urea nitrogen to creatinine ratio: 12:1-20:1 Above normal: 1. Alienation, hyperthermia, taking drugs such as steroids and tetracycline, stress status, etc. 2, high protein diet (especially when renal insufficiency), gastrointestinal bleeding. 3, urea reabsorption into the pre-renal, dehydration, cardiac insufficiency, hypoproteinemia, blood volume reduction, hepatorenal syndrome. Post-renal urinary tract obstruction, ureteral anastomosis. Kidney tubular urea permeability congenital hyperactivity (familial hyperurea). negative: Positive: Tips: Scr and BUN can reflect the degree of damage of glomerular filtration function to a certain extent. Normal value 12 to 20:1 (varies by food and test methods). Clinical significance 1. Raise (1) Alienation, fever, taking drugs such as steroids and tetracycline, stress, etc. (2) High protein diet (especially when renal insufficiency), gastrointestinal bleeding. (3) Reabsorption of urea into prerenal, dehydration, cardiac insufficiency, hypoproteinemia, decreased blood volume, hepatorenal syndrome. Post-renal urinary tract obstruction, ureteral anastomosis. Kidney tubular urea permeability congenital hyperactivity (familial hyperurea). 2, lower (1) Hunger, low protein diet. (2) Combined with severe liver failure. (3) Diuretic. (4) Dialysis. High results may be diseases: liver and kidney syndrome, urinary tract obstruction precautions High creatinine causes disturbances and disorders in metabolism in the body, such as sodium metabolism, potassium metabolism, water and electrolyte disorders, resulting in hyperemia and hypoemia, as well as polyuria, nocturia, and edema. It can also cause diseases in various systems in the body, such as the respiratory system, digestive system, respiratory system, blood system (renal anemia), and circulatory system. Inspection process Take a 16 mm × 100 mm test tube, add 0.5 ml of serum (pulp), then add 4.5 ml of 35 mmol / L tungstic acid solution, and mix well. Centrifuge at 3000r/min for 10min, and take the supernatant for use. Another three tubes were taken, indicating the measuring tube "U", the standard tube "S", and the blank tube "B". Add the protein-free blood filtrate to the measuring tube, add 3.0 ml of the creatinine standard application solution to the standard tube, add 3.0 ml of distilled water to the blank tube, and then add 1.04 mol/L of picric acid reagent 1.0 ml to each tube, and add 0.75 mol/L sodium hydroxide. 1.0 ml of the solution, mixed by inversion, placed for 15 min, at a wavelength of 510 nm, with a spectrophotometer, with a blank tube adjusted to "0", respectively, read the absorbance of the measuring tube and the standard tube. Not suitable for the crowd no. Adverse reactions and risks no.

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