Glomerular Filtration Rate (GFR)

The amount of filtrate produced by the two kidneys per unit time is called glomerular filtration rate (GFR), which is about 125 ml/min in normal adults. The ratio of glomerular filtration rate to renal plasma flow is called the filtration fraction. The renal plasma flow rate per minute is about 660 ml, so the filtration fraction is 125/660 x 100% ≈ 19%. This result indicates that about one-fifth of the plasma flowing through the kidney is filtered into the sac by the glomerulus to produce primary urine. Glomerular filtration rate and filtration fraction are indicators of renal function. Basic Information Specialist classification: urinary examination classification: urine / kidney function test Applicable gender: whether men and women apply fasting: not fasting Analysis results: Below normal: 1. Various primary and secondary kidney diseases that affect glomerular filtration. 2. GFR will gradually decrease with age, and GFR will decrease by 1.15ml/min every year after 40 years old. Normal value: Glomerular filtration rate: 110-140ml/min Above normal: 1, early diabetic glomerulosclerosis, due to increased growth hormone secretion, promote glomerular hypertrophy, elevated GFR. 2, some small lesions of nephrotic syndrome, due to glomerular capillary colloid osmotic pressure decreased, and glomerular lesions are light, so the steelmaking furnace increased. 3, GFR can be increased during pregnancy, return to normal after delivery. negative: Positive: Tips: Please cooperate with the doctor when checking. Normal value Males are (125 ± 15) ml / min, women are about 10% lower. Clinical significance GFR is used for early understanding of renal dysfunction and can be used to estimate the extent and development of functional nephron loss during the course of chronic kidney disease, and to guide the diagnosis and treatment of kidney disease. 1, GFR increased, can be seen in (1) Early stage of diabetic glomerulosclerosis, due to increased growth hormone secretion, promote glomerular hypertrophy, and elevated GFR. (2) Some small lesion nephrotic syndrome, due to decreased ossicular capillary colloid osmotic pressure, and glomerular lesions are light. (3) GFR can be increased during pregnancy and return to normal after delivery. 2, GFR reduction, can be seen in (1) Various primary and secondary renal diseases that affect glomerular filtration function. (2) GFR will gradually decrease with age, and GFR will decrease by about 1.15 ml/min every year after 40 years old. High results may be diseases: pediatric diabetic nephropathy, diabetic nephropathy, diabetic nephropathy Contraindications: 1. After urography or arteriography. 2, after the application of diuretics, laxatives, antihypertensive drugs. 3. When the body is dehydrated or edema. Inspection process 1. On the morning of the test, rest on an empty stomach, drinking water at 500 ml at 7 o'clock, and indwelling the catheter. 2, 7:30 take urine 10ml, venous blood 2ml (test blank). 3. Immediately inject a sterile 200 g/LPAH solution into the mixture at a dose of 0.4 ml/kg body weight within 10 minutes, and then add 500 ml of physiological saline solution in a solution of 10 ml of a 200 g/LPAH solution for maintenance infusion. 4. At 8:30, clamp the catheter. At 8:50, 4 ml of venous blood was taken, followed by emptying the bladder and measuring the amount of urine. The bladder was rinsed with 20 ml of physiological saline, and 20 ml of air was injected to drain the fluid in the bladder. The rinse solution was combined with urine, mixed, and 10 ml was taken to determine the PAH content. 5, 9:10, the first repeated blood and urine samples; 9:20 second repeated blood and urine samples (same operation 4). 6. Determine the PAH concentration according to the procedure. Mix each time the reagent is added and place for 3 min. The color development was stable (10-15 min) and the blank tube was zeroed at 540 nm, and the absorbance values ​​of the tubes were read. 7. Determine the glomerular filtration fraction. Not suitable for the crowd no. Adverse reactions and risks no.

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