Serum liver cancer ferritin

Hepatoma ferritin (HF) is a ferritin isolated from liver cancer cells. Ferritin consists of 24 subunit empty protein shells and 4500 iron atoms. The 24 subunits of ferritin are divided into two types, H and L. The H subunit is larger and is more acidic in myocardial ferritin; the L subunit is smaller and alkaline, and higher in hepatocyte ferritin. The molecular weight of ferritin is about 450kD. Hepatoma cells contain a kind of special ferritin that is not found in normal liver cells and fetal liver in early pregnancy. It has a high H subunit content, is acidic, and has an isoelectric point of 5.1. This method uses monoclonal antibodies against HF to establish an ELISA method.

The material in this site is intended to be of general informational use and is not intended to constitute medical advice, probable diagnosis, or recommended treatments.