Unheated serum reagin

The unreacted serum reactin experiment uses a modified VDRL antigen, that is, the VDRL antigen is diluted with a dilution solution and centrifuged to precipitate, and EDTA, choline chloride and a preservative are added to the precipitate. The sensitivity and specificity are similar to VDRL. EDTA can make the antigen invariant within half a year, choline chloride can inactivate complement, etc., the use of serum can be inactivated without heating. Antigen does not need to be prepared every day, and can be stored in a refrigerator at 4-8 ° C for six months. Cardiolipin is used as an antigen to measure anticardiolipin antibodies in serum, also known as reactin. This test has high sensitivity and low specificity, and is prone to biological false positives. After adequate treatment of patients with early syphilis, reptin can disappear, and those who have not been treated early to late can also reduce or disappear in some patients. Currently it is generally used as a screening and quantitative test to observe efficacy, recurrence and reinfection.

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