Congenital agammaglobulinemia

Because the body lacks B lymphocytes or B cell dysfunction, it cannot differentiate into mature plasma cells after being stimulated by the antigen, or the synthesized antibodies cannot be excreted from the cells, resulting in a deficiency of immunoglobulin in the serum and causing this type of disease. In general, there are defects in B cell differentiation and maturation at different stages. The expression of serum immunoglobulins in one, several or subclasses is reduced and the ability to produce antibodies is low. Even if serum immunoglobulin levels are normal or elevated, severe clinical manifestations should be highly suspected of the presence of antibody production disorders. Congenital X-linked agammaglobulinemia is also called Bruton type agammaglobulinemia. Belongs to primary body fluid deficiency.

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