Hereditary complement deficiency

Almost every component of the complement system can be genetically defective. Most of the complement genetic defects are autosomal recessive, a few are autosomal dominant, and the properdin deficiency is X-linked recessive. Complement deficiency is often accompanied by immune disease and repeated bacterial infections. In general, the first front-end response components of the complement system, such as C1, C4, and C2 defects, are often accompanied by immune complex diseases, especially SLE; the lack of factors C3, H, and I increases patients' bacterial infections Patients with deficiencies in properdin, C5, C6, C7, and C8 are susceptible to severe nausea infections.

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