Pediatric adult chronic myelogenous leukemia

In 1951, Damesek first proposed that chronic myelogenous leukemia (CML), erythrocytosis, primary thrombocytosis, and idiopathic myeloid metaplasia (AMM) are all related to myeloproliferative syndrome. Although each disease has unique clinical, laboratory, and biological characteristics, the common feature is the polyclonal proliferation involving whole myeloid cells, indicating that the disease occurs in pluripotent hematopoietic stem cells. Chronic leukemia is rare in childhood, accounting for 3% to 5% of childhood leukemia. The clinical manifestations of CML in infants are significantly different from those of adults, so children's CML is generally divided into juvenile and adult types. The age of onset of adult chronic myelogenous leukemia in children is more than 5 years old, more common in 10 to 14 years old, rarely seen in children under 3 years old, and there is not much difference between men and women.

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