Monoclonal gamma globulin disease with peripheral neuropathy

Monoclonal gamma globulin disease with peripheral neuropathy is also called paraproteinemic peripheral neuropathy. When there is too much M protein in the blood, it is called monoclonal gammopathy, also known as immunoglobulin disease, paraprotein disease, or plasma cell disease. The pathological significance of the presence of M protein in the blood on peripheral nerves is that the M protein contains one or more antibodies against myelin or axon membranes, such as anti-MAG, GM1, and GD1 antibodies. Among the idiopathic peripheral neuropathies of unknown cause, 10% are associated with monoclonal globulopathy, and monoclonal gammopathy of undetermined significance (MGUS) is 29% -71% with peripheral neuropathy It is suggested that monoclonal glycinopathy is related to peripheral neuropathy.

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