Atropine poisoning in children

I. Overview: Atropine and scopolamine. Plants containing atropine alkaloids include Datura, White Datura (Daffodil), Gardenia (Tianxianzi), Mandrill, etc .; synthetic substitutes for atropine include post-matropine. , Weifukang (Benatiqin), Anisodamine (654-2), Antan (benzenisoline), etc. The toxic effect is to block a series of reactions caused by acetylcholine receptors, which first excite and then inhibit the central nervous system. Mandala poisoning (daturism) refers to the poisoning produced in children after excessive consumption of mandala and its preparations. Daturas are also known as wildflowers and belladonna, with many types and different names in different places. They are annual wild herbaceous plants that grow in various parts of our country. The main component is alkaloids such as scopolamine, atropine, scopolamine, which are distributed throughout the plant. The extract is formulated into belladonna mixture, which has the effects of spasmolysis and relief of abdominal pain. The composition and content of each mandala are different, and the content of each part of the whole plant is also different. The eggplant fruit is the highest, and excessive amounts can be poisoned. Children take orally 3 to 8 eggplants to poison. Tritium poisoning refers to poisoning produced by children after eating too much tritium and using scopolamine preparations. Cormorant is a plant of the same family of Datura. Its leaves, roots, flowers and seeds are poisonous. It is commonly grown in Xinjiang, Inner Mongolia and other places, and children mistakenly think that their rhizomes are ldquo; wild radish rdquo ;, excessive eating can be poisoned. It mainly contains scopolamine, and its toxic effect is also to block the acetylcholine receptor, and its toxic symptoms are similar to those of Datura. In the past 20 years, research and use of scopolamine (anisodamine, scopolamine) has been extensive, and it has been found that it has protective effects on injured myocardial cells, nerve cells, kidney tissues and lung tissues, asthma, multiple organ dysfunction syndrome, etc. It has therapeutic effects; atropine and scopolamine can improve microcirculation and anti-shock. In recent years, it has also been used as an adjuvant to treat brain diseases and neurological rehabilitation. With the increase in clinical application of scopolamine preparations, the chance of poisoning caused by excessive or overdose will also increase.

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