Pulmonary eosinophil histiocytosis

Eosinophils histiocytosis of the lung, previously included in histiocytosis X (HX). Langerhans cell histiocvtosis (LCH) is currently considered more appropriate, as recent studies have shown that the main lesion in this group of diseases is the clonal proliferation of Langerhans histiocytes. It manifests as disseminated acute lesions (Letter-Siwe disease), chronic multifocal lesions (Hand-Schuller-Christian), and slow-moving focal lesions (eosinophilic granuloma) in infants and young children. Lungs in the lungs can be part of a multisystem lesion or restricted to the lungs (eosinophilic granuloma, primary lung LCH). Primary lung LCH is a rare smoking-related interstitial lung disease that occurs mainly in young adults. Rarely, there are only isolated osteolytic lesions; more rare are multifocal or widely disseminated lesions, similar to pediatric Letter-Siwe disease. Progressive lesions are similar to IPF; however, the disease is generally a benign and persistent clinical course. Although LCH has some similarities with other diffuse interstitial lung diseases, as an independent disease, it has different clinical, radiological and pathological manifestations from other diseases.

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