Amphetamine poisoning

Amphetamine (benhetamine, benzedrine) is a non-catecholamine sympathomimetic drug that excites alpha; and beta; adrenergic nerve endings, stimulates the central nervous system and the heart and respiratory organs, has elevated hypertension, constricts peripheral blood vessels, excites the heart, relaxes the bronchus And intestinal muscles, dilated pupils, contraction of the bladder sphincter and so on. The therapeutic dose reduces fatigue and produces a feeling of self-euphoria. It is used clinically for narcolepsy, poisoning by anesthetics and other central inhibitors, and depression. The drug is administered from the intestine or parenterally, and is quickly absorbed after 1 to 2 hours. About 30% to 40% of the drug is destroyed by deamination in the liver, and the remaining unchanged drugs are mainly excreted in the urine. Acidic urine can promote its excretion. To those who are sensitive to this medicine, only 2mg can cause symptoms of poisoning. The general poisoning dose is 15-20mg at one time, and 30mg will have severe reactions. The minimum lethal dose for adults is about 250 mg, and rapid intravenous injection of 120 mg can be lethal. Long-term application can tolerate large doses, and once used 400 to 500 mg and survived.

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