Hereditary multiple cerebral infarction dementia

Hereditary multi-infarct dementia also known as autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) Van Bogaert (1955) The two sisters reported middle-aged and rapidly progressing Binswanger subcortical encephalopathy, manifested as dementia, gait instability, pseudobulbar palsy, epilepsy, and focal neurological deficit. The other two sisters in the family due to progressive dementia were Died at 36 and 43 years. Sourander et al. (1977) reported inherited multiple cerebral infarct dementia, and Stevens et al. Reported chronic familial vascular encephalopathy with autosomal dominant inherited stroke families of unknown etiology. Diseases are mainly damage to the pia mater and deep brain arteries, and thickening of blood vessel walls causes reduced blood flow and occlusion.

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