Polygenic genetic disease

Polygenic inherited diseases are a common disease with complex etiology and high incidence. Multigene inherited diseases or traits are controlled by multiple pairs of alleles. It can also be said that they are controlled by multiple minor genes. The minor genes are not dominant or recessive. They are codominant and have cumulative effects. Affected by environmental factors. To analyze and study the etiology, pathogenesis, and recurrence risk estimates of polygenic inherited diseases, the dual roles of genetic and environmental factors must be considered. Polygenic inherited traits and diseases are different from single genes, and their mutations are continuous in a population, and there are only quantitative differences among different individuals. Such as the height of a person, the variation in the crowd is continuous. Polygenic genetic disease refers to a genetic disease determined by multiple pathogenic genes. Often manifested as familial aggregation. The incidence of polygenic genetic diseases is far lower than that of single genetic diseases. Because in addition to the incidence of genetic factors, environmental factors also play a very important role in this type of disease. Such as schizophrenia, asthma, hypertension, diabetes, and certain congenital deformities such as cleft lip, palate, spina bifida, etc. are all genetic diseases.

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