Lattice corneal dystrophy

Lattice corneal dystrophy is a hereditary corneal lesion with reticular turbidity and severe visual impairment in the symmetrical corneal stroma of both eyes. First described by Biber (1890). Later, Haab (1899) and Dimmer (1899) successively reported some hereditary cases. Fuchs (1902) further confirmed the familial genetic predisposition. Bucklers (1938) reported a typical lineage. In 1967, Kintworth confirmed that the disease is a genetic variation of amyloidosis that is limited to corneal onset. At present, five clinical types Ⅰ, Ⅱ, Ⅲ, ⅢA, and Ⅳ have been found. Among them, type Ⅰ clinical is more common, and many cases have been reported in China. Hu Ningning has reported 5 pedigrees in China with 31 cases. Twenty-five of the 46 offspring of the patients developed the disease, and the incidence was 52.9%.

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