Alzheimer's disease

Alzheimer's disease (AD) is dementia caused by chronic progressive central nervous system degeneration. It is the most common cause of dementia and the most common senile dementia. AD is characterized by neuropsychiatric symptoms such as progressive memory impairment, cognitive dysfunction, personality changes, and language disorders. Onset usually occurs in the elderly or in the pre-senile period, and it usually develops slowly, and gradually progresses. Dementia is the main manifestation, and the onset of the disease occurs in the elderly or has a family history of the same disease, and the condition develops rapidly. 10% of AD patients with genetic quality and genetic mutations have a clear family history, especially those who have developed disease before 65 years of age, so family history is an important risk factor. Some people think that about 50% of first-degree relatives of AD will develop disease between 80 and 90 years of age. The risk is There is no family history of 2 to 4 times AD, and early-onset autosomal dominant abnormal AD is relatively rare. Currently, only 120 families worldwide carry identified disease-causing genes. Genes related to the onset of FAD include 21, 14, and 1 Chromosomes No. 19 and 19 have been found to date, FAD is an autosomal dominant genetic disease with genetic heterogeneity.

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