Exfoliation syndrome

Exfoliation syndrome (pseudoexfoliation) is a kind of abnormal protein synthesized by a variety of eye tissues, which blocks the trabecular meshwork and causes trabecular hypofunction. Elevated intraocular pressure causes glaucoma. The exfoliation appears as gray or blue-white amorphous protein debris, which is not limited to the anterior lens capsule and can be found on other ocular tissues with a basement membrane, such as the ligament, cornea, iris, ciliary body, anterior vitreous surface, and eye Some external tissues, such as conjunctival vessels and orbital tissue near the posterior pole of the eyeball, can also be called basement membrane syndrome. Trabecular meshwork often has significant pigmentation and can sometimes extend up to the Schwalbe line. The accompanying glaucoma has a worse response to drug treatment than primary open-angle glaucoma. In 1917, Lindberg first described the deposition of detrital material in the margins of the pupils of these chronic glaucoma, and revealed that this deposit originated in part from the exfoliated anterior lens capsule. Histochemically proved that the debris of the anterior lens capsule is different from the lens capsule, and the lesion does not involve the lens capsule. Therefore, pseudo-exfoliation is proposed to distinguish the true exfoliation of the lens capsule of glass workers at high temperature. The name "syndrome" is more appropriate.

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