Primary thrombocytopenic purpura

Primary thrombocytopenic purpura, or idiopathic thrombocytopenic purpura (ITP), refers to thrombocytopenia without obvious exogenous causes, but most of them are increased platelet destruction due to immune response. Therefore, it is also known as autoimmune thrombocytopenia, which is a more common type of hemorrhagic blood disease. It is characterized by shortened platelet life and increased megakaryocytes in bone marrow. 80% -90% of cases have IgG antibodies on the serum or platelet surface, and no obvious spleen Swelling. According to the pathogenesis, inducing factors and course of disease, ITP is divided into two types: acute and chronic. 80% of children are acute type (AITP), there is no gender difference, and the disease is easy to occur in spring and winter. Once the cause is cleared, the disease will be cured in June-December. However, more than 95% of adult ITP is chronic (CITP), and the ratio of male to female is about 1: 3. It is generally considered to be a type of autoimmune disease, and it is difficult to survive. The case fatality rate is about 1%, most of which are due to intracranial hemorrhage. The main clinical manifestations of ITP are bleeding from the skin and mucous membranes or visceral bleeding.

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