Hypogonadism

Gonadal dysplasia: also known as Turner syndrome, type xo, lacks an X chromosome. It is a sex chromosome genetic disease. Due to the abnormal sex chromosome, the ovary cannot grow and develop, so the ovary is a strip-shaped fibrous tissue without primitive follicles and eggs. Therefore, the lack of female hormones, which leads to the development of secondary sexual characteristics and primary amenorrhea, is the only surviving monomer syndrome in humans. Typical gonadal dysplasia presents height and weight loss at birth, obvious swelling of the back of hands and feet, and loose skin on the side of the neck. Postnatal birth height growth is slow, the main clinical features are: female phenotype, low back hairline, 50% with cervical webbed; shield-shaped chest, widening of nipple spacing; elbow eversion and multiple moles. About 35% of children are accompanied by cardiac malformations. Aortic constriction is more common. In addition, kidney malformations (such as horseshoe kidney, ectopic kidney, hydronephrosis, etc.), dysplasia of the toenails, shorter metacarpals 4, 5 and more moles, etc. are still visible. The child's external genitalia has remained infantile. The labia minora is dysplastic and the uterus cannot be touched. Most children are intelligent. Often due to stunted growth, adolescent asexual development, and primary amenorrhea. No treatment can promote ovarian development, nor can it restore patient fertility. The purpose of treatment is to promote height and stimulate breast and reproductive organ development.

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