Loss of salt

Salt loss refers to a disease that causes the body to lose too much salt due to various reasons. Salt loss can cause salt loss nephritis and pseudoaldosteronism. Salt loss nephritis, also known as Thorn syndrome, is currently considered to be a special type of certain kidney diseases that are characterized by severe renal salt loss. Salt loss nephritis is a renal tubular dysfunction caused by various reasons. It was first reported by Thorn in 1944, so it is also called Thorn syndrome. It is a special group of certain kidney diseases characterized by severe renal salt loss, most commonly seen in chronic pyelonephritis, followed by renal medulla cystic disease, polycystic kidney disease, and renal calcification. The prominent clinical manifestation of this disease is hyponatremia, which can lead to circulatory failure, low pulse rate, decreased blood pressure or orthostatic hypotension, syncope, and peripheral vein collapse. Patients are often accompanied by dehydration, poor skin elasticity, eyeball depression, Muscle weakness, loss of appetite, nausea and vomiting, weight loss, and severe muscle spasms. If sodium salts are not supplemented in time, patients may die due to uremia caused by water loss, salt loss, and a rapid decrease in glomerular filtration rate. In this disease, blood sodium and blood chlorine are reduced, but blood potassium is slightly higher, blood urea nitrogen can also be increased to varying degrees, and often metabolic acidosis, continued increase in sodium, and increased aldosterone excretion in urine, etc. Go to the hospital for examination and treatment in time. Pseudohypoaldosteronism, also known as Cheek-Perry syndrome, was first reported by Cheek and Perry (1958) and is a rare type of salt loss syndrome. The age of onset is mostly in the neonatal period. Symptoms such as repeated vomiting, diarrhea, and loss of thirst may occur within a few hours of life. Growth and development are the main symptoms (even idiots); in some cases, salt is limited or aldosterone antagonists are used. Symptoms are revealed and they resolve on their own with age. It is clinically believed that the cause of this disease is caused by the lack of aldosterone receptors on the target organs of the patient (tubules, salivary glands, sweat glands, and colon), or the reduction or complete inability of binding of aldosterone to its receptors; molecular biology and molecular biochemical Further research found that the etiology of pseudoaldosteronism is genetically determined dysfunction of sodium channels on the cell membrane. The target organs of recipients in different patients are not necessarily the same, and the degree of salt loss in clinical manifestations is also different. Since most patients can trace their family history of salt loss, it has been reported that this disease is a hereditary disease, and the genetic pattern can be expressed as autosomal dominant inheritance or autosomal recessive inheritance.

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