Excessive accumulation of lactic acid

Lactic acid is the product of carbohydrate hypoxia metabolism. Lactic acid production increases when tissue is hypoxic. For the human body, lactic acid is one of the fatigue substances. It is a waste generated during the body's maintenance of body temperature and body movement to generate heat. Accumulation of lactic acid is a chemical disorder in the body that can have fatal consequences. Higher lactic acid concentrations lead to lactic acidosis. The breakdown of glucose is divided into aerobic oxidation and anaerobic fermentation. Aerobic oxidation refers to the main pathway for energy production from sugar breakdown in the body. Glucose is decomposed into lactic acid under anaerobic conditions. Although it is not the main way to generate energy, it has important pathological and physiological significance. Under normal circumstances, pyruvate produced by glycolysis is mostly produced in fat, muscle, brain and other tissues. Carboxylic acid is oxidized cyclically, but a small part is catalyzed by pyruvate carboxylase (PC) to enter glycogen through oxaloacetate. In the liver and kidney, sugar pyruvate is regenerated into the tricarboxylic acid cycle and pyruvate dehydrogenation is required. Enzymes (PDH) and coenzyme (NAD) catalyze PDH is inhibited when diabetes and starvation, and NAD is also insufficient, the reduction of pyruvate to lactic acid plus insufficient ATP, and the pyruvate carboxylase (PC) catalysis is limited, so glycogen Health also decreases, and pyruvate is converted to lactic acid, which causes the blood lactic acid concentration to rise sharply. During liver cirrhosis, the conversion of lactic acid to liver glycogen is impeded. Excessive lactic acid accumulation after muscle activity causes fatigue.

The material in this site is intended to be of general informational use and is not intended to constitute medical advice, probable diagnosis, or recommended treatments.