Increased urate deposition in joints

Uric acid deposits increase in the joints, and the inflammation recurs into a chronic stage and cannot completely disappear, causing joint bone erosion and defect and surrounding tissue fibrosis, resulting in joint stiffness and deformity, and limited movement. There are repeated episodes of acute inflammation, which make the lesions more and more serious, and the deformities are more and more obvious, which seriously affects joint function. Some patients have mild atypical symptoms in the acute phase, and they will not be discovered until joint deformities appear. A small number of chronic arthritis can affect the whole body joints including large joints such as shoulder and hip and spine. In addition, urate crystals can be deposited in the tendons, tendon sheaths, and skin connective tissue near the joints to form yellow-white, different-sized raised neoplasms, called sore gout nodules (or gout stones), as small as sesame and as large Eggs or larger, often occur in the ear wheels, forearm extension, metatarso, fingers, elbows, etc., but do not involve the liver, spleen, lungs and central nervous system. Nodules are soft at the beginning, and become harder with fibrous tissue proliferation. The nodules near the joints are easy to wear, and the outer skin is very thin, which easily breaks into fistulas. White powdered urate crystals can be discharged, but secondary infections are rare due to the bacteriostatic effect of urate. The tissue around the fistula was chronic inflammatory granulomatous and difficult to heal.

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