Muscarinic symptoms

Introduction The symptoms of muscarinic poisoning are the main manifestations of organophosphorus pesticide poisoning, which are manifested by the increase of various glandular secretions and the symptoms and signs of smooth muscle contraction in the body, such as excessive sweating, runny, tearing, rhinorrhea, and dry and wet lungs. Voice, difficulty breathing. Nausea and vomiting, abdominal pain, diarrhea, bowel sounds, urinary urgency, incontinence. The pupil is reduced, the vision is blurred, the vascular smooth muscle is inhibited, and the blood pressure is lowered. Inhibition of acetylcholinesterase causes accumulation of acetylcholine, which causes the cholinergic nerve to be continuously impulsive, leading to excitement and post-depletion.

Cause

The main mechanism of muscarinic symptoms in organophosphate poisoning is sympathetic nerve stimulation, which causes smooth muscle spasm and exocrine gland secretion, and severe pulmonary edema or respiratory failure. Central nervous system symptoms The central nervous system is dizzy, headache, fatigue, ataxia, irritability, paralysis, convulsions and coma after being stimulated by acetylcholine.

an examination

Related inspection

Blood routine urine blood pressure

The muscarinic symptoms are the main clinical manifestations of acute poisoning of organophosphorus pesticides. The muscarinic symptoms mainly include early appearance, nausea, vomiting, excessive sweating, runny nose, dilated pupils, severe breathing difficulties, and pulmonary edema.

Determination of chE activity: ChE activity decreased to 70% of normal value, it has clinical significance, and it is more serious when it is reduced to 50% or less. The vomit or gastric contents of oral poisoning have the significance of diagnosis, and can also detect organic urine. Phosphorus metabolites, but the clinical attention should be paid to the fact that the degree of poisoning is not related to the degree of poisoning.

Differential diagnosis

Acute poisoning should be differentiated from acute toxic liver disease and kidney disease caused by viral hepatitis, drug-induced hepatitis and other toxicants.

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