Fatty infiltration

Introduction Fatty infiltration refers to the appearance of fat cells in the interstitial organs of normal fat-free cells, also known as interstitial fat infiltration.

Cause

1, the cause and mechanism

Common in aging and obese animals, it may be due to the decreased function of circulating mesenchymal cells in aged animals.

2, pathological changes

It mainly occurs in the heart, pancreas, skeletal muscle and lymph node tissue. For example, in the heart, accumulated fat cells can infiltrate through the heart wall, and the adipose tissue deposition area below the endocardium can be seen by the naked eye. Microscopic examination of adipose tissue between myocardial fibers.

3. The outcome and impact on the body

Fat infiltration generally does not affect the function, but the fat infiltration of vital organs, even to a lesser extent, will affect the normal function of the organ, and may even cause organ failure.

It mainly occurs in tissues such as heart, pancreas and skeletal muscle. For example, when the heart muscle develops fat, the fat can infiltrate through the heart wall to the subendocardium. Under light microscopy, fat cells are arranged between cardiomyocytes, distributed in strips or strips, myocardial fibers can be atrophied due to compression, and the heart appears pseudo-hypertrophy in appearance.

an examination

Related inspection

Ultrasound diagnosis of liver disease

First, patients with fatty liver have some simple clinical manifestations such as pain, tenderness and hepatomegaly in the liver. A small number of patients may have mild jaundice. Individual critically ill patients may have symptoms such as ascites and lower extremity edema. Among them, hepatomegaly is the most common. In these cases, the doctor will check through palpation, B-ultrasound or CT and consultation, which is simple and painless.

Then blood tests, the total amount of plasma protein in patients with fatty liver and the inversion of albumin and globulin ratio are the most common biochemical abnormalities. Fatty liver infiltration, about 30% of patients with serum total bilirubin per liter more than 1 mg, a small number of patients with direct bilirubin increase and urinary bilirubin positive. As hepatocytes are damaged, the enzymes in the liver cells enter the blood, and the alanine aminotransferase and serum alkaline phosphatase in the blood increase accordingly. Of course, the most accurate diagnosis is obtained through liver biopsy. In addition, occasional patients with severe pain in the liver area with abdominal rebound pain, fever, elevated white blood cells and other symptoms, because of the acute abdomen and need to be surgically explored, the hepatomegaly is grayish yellow.

Most patients can be diagnosed basically by the first few non-invasive tests and blood tests.

Differential diagnosis

Anyone who has ultrasound diagnosis of fatty liver must also combine clinical manifestations and liver biopsy if necessary to confirm the diagnosis. If patients with chronic hepatitis are treated with fat, that is, reduce calorie intake and increase physical activity, it will make the condition worse, so it should be noted.

Identification of hepatitis with fat and fatty liver infiltration: How to distinguish whether it is simple fatty liver or chronic hepatitis with fat infiltration? First, patients with fatty liver will have some simple clinical manifestations such as pain in the liver area, tenderness and hepatomegaly, a few The patient may have mild jaundice, and some severely ill patients may have symptoms such as ascites and lower extremity edema. Among them, hepatomegaly is the most common. In these cases, the doctor will check through palpation, B-ultrasound or CT and consultation, which is simple and painless.

Then blood tests, the total amount of plasma protein in patients with fatty liver and the inversion of albumin and globulin ratio are the most common biochemical abnormalities. Fatty liver infiltration, about 30% of patients with serum total bilirubin per liter more than 1 mg, a small number of patients with direct bilirubin increase and urinary bilirubin positive. As hepatocytes are damaged, the enzymes in the liver cells enter the blood, and the alanine aminotransferase and serum alkaline phosphatase in the blood increase accordingly. Of course, the most accurate diagnosis is obtained through liver biopsy. In addition, occasional patients with severe pain in the liver area with abdominal rebound pain, fever, elevated white blood cells and other symptoms, because of the acute abdomen and need to be surgically explored, the hepatomegaly is grayish yellow. Most patients can be diagnosed basically by the first few non-invasive tests and blood tests.

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