Lipodystrophy

Introduction Lipodystrophy, also known as fat redistribution, is a disorder in your body that produces, uses, and stores fat. There are two different fat transfers. One is that fat loss is also called muscle atrophy, and fat is lost from some part of the body, especially arms, legs, face and buttocks. The other is fat accumulation, also called obesity. Fat accumulates in specific parts of the body, especially the stomach, chest and back neck.

Cause

There is now evidence that lipodystrophy is associated with the administration of certain nucleoside reverse transcriptase inhibitors such as stavudine (d4T) and protease inhibitors such as indinavir (IDV). For example, stavudine can cause fat loss. Protease inhibitors increase the risk of fat accumulation. The longer you take these drugs, the more likely you are to have a fat metabolism disorder.

Lipodystrophy and other factors include:

1. Age-aged fat metabolism disorder is more risky

2. Sex - Men are more likely to lose fat on their arms and legs, while women tend to increase fat in the abdomen and chest.

3, the time and severity of HIV infection - the longer the infection, the more serious the risk of your fat metabolism disorder.

4. Physical indicators in the range of obesity or major changes in body weight may be factors of lipodystrophy.

5. The original level of the immune system and the recovery of the immune system after antiviral therapy are all influencing factors.

an examination

Related inspection

Blood lipid examination blood glucose hemorheology check serum acetoacetate

The diagnosis of lipodystrophy is usually determined by examining changes in your body fat. Your doctor may measure your arms, thighs, waist, hips, and neck regularly before and during your medication; however, there is currently no specific recommendation for the detection and evaluation of lipodystrophy.

Differential diagnosis

Differential diagnosis of lipodystrophy:

1, subcutaneous fat atrophy: fat malnutrition, also known as subcutaneous fat atrophy, fat dystrophy. In 1885, Weir-Miechell first reported partial lipodystrophy (lipodystrophy), and later reported that the patient had neck, arms, chest and abdomen fat malnutrition, with increased fat deposition in the hips and legs, Lawrence reported in 1946 Complete fat dystrophy, patients with malnutrition are systemic, completely or patchy, and fat deficiency is often accompanied by a series of metabolic disorders.

2, subcutaneous fat increase: obesity (Obesity) refers to the body caused by a variety of fat components, significantly more than the normal average amount of normal people called obesity. The fat stored under the skin accounts for about 50% of the total fat. Obesity can occur at any age, is more common in middle-aged people, and more women than men. The weight gain of obese people is due to the increase of adipose tissue, while the muscle tissue does not increase or decline, but the athletes' muscles are particularly developed, or the weight gain of edema is not included. When the calorie intake exceeds the body's consumption, the excess calories are stored in the body in the form of fat, so that those who weigh more than 20% of the standard weight are obese, more than 10% are overweight; and according to height and weight, the body mass index (weight team/ Height] calculated, more than 24 for obesity. The World Health Organization (WH 0) standards are: men > 27, and women > 25 are obese.

3, subcutaneous fat disappears: subcutaneous fat atrophy (lipoatrophy): the occurrence may be related to the patient receiving subcutaneous or intramuscular corticosteroids. Subcutaneous fat atrophy mainly manifests as the disappearance or weight loss of progressive subcutaneous fat tissue, which may cause skin wrinkles and depression, difficulty in pinching, often on the face, and then affect the neck, shoulders, arms and trunk, some patients disappear only fat Limited to the face or half-side, half body, muscle, bone, hair, breast and sweat glands are normal, no muscle disorders, most physical strength is not affected. Most of the disease occurs around the age of 5-10, and women are more common.

The material in this site is intended to be of general informational use and is not intended to constitute medical advice, probable diagnosis, or recommended treatments.