Hepatitis B surface antigen (HBsAg) positive

Introduction Hepatitis B virus surface antigen (HBsAg) is an outer membrane protein of hepatitis B virus (HBV) that can occur early after infection with HBV. Hepatitis B surface antigen (HBsAg) is a coat protein of hepatitis B virus, which is not infectious in itself, but its appearance is often accompanied by the presence of hepatitis B virus, so it is a marker of hepatitis B virus infection. It can be present in the patient's blood, saliva, milk, sweat, tears, nasopharyngeal secretions, semen and vaginal secretions. Two to six months after infection with hepatitis B virus, a positive result can be detected in serum 2 to 8 weeks before alanine aminotransferase is elevated. Most patients with acute hepatitis B can turn negative in the early stage of the disease, and this indicator can be positive for patients with chronic hepatitis B.

Cause

Hepatitis B surface antigen (HBsAg) positive cause:

Hepatitis B virus infection.

Hepatitis B surface antigen usually appears after 1 to 2 weeks of infection with hepatitis B virus, which means hepatitis B virus infection. Hepatitis B surface antigen positive (+) is a marker of HBV infection. If liver function and other HBV infection indicators are normal and only hepatitis B surface antigen is positive, and no symptoms or signs are found, it may be hepatitis B surface antigen carrier or previous hepatitis B. The liver function has returned to normal, but hepatitis B surface antigen Not yet turned negative.

an examination

Related inspection

Serum pre-S2 protein serum anti-S2 protein serum pre-S1 protein

Hepatitis B surface antigen (HBsAg) positive examination diagnosis:

The most commonly used method for measuring surface antigens in China is the enzyme-linked immunosorbent assay (ELISA), followed by the radioimmunoassay (RIA).

The ELISA is simple, convenient and rapid. The minimum concentration of serum surface antigen that can be detected in the imported kit is 0.2 ng/ml, and the domestic kit can reach 0.5 ng/ml.

The normal values of hepatitis B surface antigen mainly include the following methods:

1, ng / ml notation:

If the normal value of hepatitis B surface antigen (ng/ml) is greater than 0.18 ng/ml, it means that the patient has hepatitis B virus, hepatitis B surface antigen and is regarded as a positive result, and vice versa.

2. S/CO value representation:

If the normal value of hepatitis B surface antigen (S/CO) is greater than 1S/CO, it means that the patient has hepatitis B virus, hepatitis B surface antigen and is considered as a positive result, and vice versa.

3. S/N value representation:

The AXSYM immunoassay analyzer obtains the value of S/N. If the normal value of hepatitis B surface antigen (S/N) is greater than 2.1 S/N, it means that the patient has hepatitis B virus, hepatitis B surface antigen and is regarded as a positive result, and vice versa. It is considered negative.

Differential diagnosis

Hepatitis B surface antibody (anti-HBs) positive: at least three problems: (1) Hepatitis B patients have reached the recovery period, and will soon say goodbye to hepatitis B virus infection; (2) He has been infected with hepatitis B virus, may have hepatitis B disease, or may not know Unexplained recessive infection, but now the virus has been cleared, obtained immunity to hepatitis B, even if hepatitis B virus invades the body, it is still safe; (3) simple anti-HBs-term positive, is injected with hepatitis B vaccine and immune The standard of success, of course, will not be infected with hepatitis B virus.

Hepatitis B e antigen (HBeAg) positive: Hepatitis B e antigen is a direct indication of hepatitis B virus infection, and its persistent positive indicates that the virus has active replication, which may indicate chronic disease, which may lead to chronic hepatitis and cirrhosis.

Core antibody (anti-HBc) positive: After human hepatitis B virus, hepatitis B virus nucleic acid (HBV-DNA) first appears in the serum, and hepatitis B virus surface antigen (HBsAg) and e antigen appear after about 1 month. H BeAg), then anti-HBc appeared. As the condition gradually improved, HBV-DNA, HBsAg and HBeAg in the serum were negative, and hepatitis B surface antibodies (anti-HBs) appeared after a period of disappearance of HBsAg. At this time, anti-HBc and anti-HBs can be positive at the same time. Since anti-HBs persist in serum for a shorter period of time than anti-HBc, anti-HBs disappear after a period of time, and only a single anti-HBc is positive. Whether it is a clinically symptomatic hepatitis B patient or a latent infection with no clinical manifestations, after recovery, serological tests can be expressed as a single anti-HBc positive.

The pathogen serological examination can be diagnosed.

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