Drug-induced edema

Introduction Drug-induced edema refers to the disorder of body fluid balance caused by the clinical application of certain drugs, and the body fluids remain in the interstitial space and cause systemic or local swelling. Drug-induced edema refers to the phenomenon of edema in certain parts of the body due to the action of drugs after the use of certain drugs. The use of drugs such as adrenocortical hormone, testosterone, androgen, insulin, thiourea, licorice, etc., can cause swelling of the face, hands and feet, and the edema will gradually subside after stopping the drug.

Cause

Drug-induced edema-inducing drugs:

1. Furosemide: Although furosemide is a common diuretic for the treatment of edema, some women with idiopathic edema will increase the edema after a long time of application of furosemide. This is because this patient has renin-angiotensin-aldosterone system reactivity, people are prone to edema when standing, and furosemide can aggravate this effect.

2. Insulin: Drug-induced edema occurs at the stage of starting medication. The edema is limited to the lower limbs, and the severe ones can spread to the whole body. This edema often resolves within a few days.

3. Indomethacin: It is an anti-inflammatory drug commonly used for joint pain, neuralgia and muscle pain. This medicine can inhibit the formation of prostaglandins, cause water retention, and cause edema in some people.

4. Chlorpromazines: These drugs reduce sodium excretion in the body and cause edema.

5. Glucocorticoids: such as prednisone, hydrocortisone, dexamethasone, etc., can directly cause water and sodium retention, long-term use can appear upper body edema obesity. In addition, there are drugs such as heartache and heartache, which can cause different degrees of edema.

an examination

Related inspection

Urine routine blood routine

Examination and diagnosis of drug edema:

Mainly manifested as lower extremity or facial edema, severe systemic edema. It is characterized by edema occurring after administration and disappearing shortly after stopping the drug. Such as the application of adrenocortical hormone, licorice preparations, androgen, estrogen, calcium antagonists, etc., can cause edema. Drug-induced edema, as long as the drug is discontinued, edema can be dissipated and will not cause serious consequences, but it must be taken seriously.

Differential diagnosis

Symptoms of drug-induced edema :

(1) Cardiac edema: In the case of right heart dysfunction, exudative or constrictive pericarditis, edema is caused by increased venous pressure in the systemic circulation and increased capillary filtration pressure. Cardiac edema is characterized by edema that first occurs in the ptosis, often throughout the body from the lower extremities, and ascites or pleural effusion can occur in severe cases. Edema is formed at a slower rate. The edema is solid and less mobile. The main basis for the diagnosis of cardiogenic edema is the history and signs of heart disease. Determination of a significant increase in venous pressure is an important indication for diagnosis.

(2) Hepatogenic edema: cirrhosis often has mild edema of the lower extremities before the appearance of ascites, which first occurs in the ankle and gradually spreads upward. The head and face and upper limbs are often edema. Ascites and pleural effusion occur in severe cases. A variety of chronic liver disease history and signs of liver damage and laboratory indicators are the basis for diagnosis.

(3) dystrophic edema: chronic consuming disease, chronic nutritional deficiency, protein loss gastrointestinal disease, severe burns caused by hypoproteinemia, vitamin B1 deficiency, etc. can produce edema. Tissue relaxation caused by a decrease in subcutaneous fat and a decrease in tissue pressure increase the retention of water. Edema often spreads from the foot to the whole body.

(4) Systemic edema for other reasons: 1 mucinous edema: hypothyroidism, when the condition is severe, due to skin infiltration by mucin and mucopolysaccharide, producing characteristic non-depressed edema, called mucinous edema. Often occurs in front of the face and cheekbones. 2 drug edema: the application of certain drugs can cause edema, which is characterized by mild edema after medication, gradually disappear after stopping the drug. The more common drugs are adrenocortical hormone, testosterone, estrogen, insulin, etc., and the dose of Rauvolfia, thiourea and licorice can also cause edema. 3 premenstrual tension syndrome is also one of the common causes of edema, which is characterized by mild edema of the eyelids, ankles and hands 7 to 14 days before menstruation, which may be accompanied by breast tenderness and pelvic heaviness, urinating after menstruation. As the amount increases, edema and other neurological symptoms gradually subsides. 4 idiopathic edema: mainly in the sagging part of the body, more common in adult obese women, often associated with emotional and mental changes, accompanied by fatigue, dizziness, headache, anxiety, insomnia and other neurasthenia manifestations, vertical position water test is positive .

The material in this site is intended to be of general informational use and is not intended to constitute medical advice, probable diagnosis, or recommended treatments.