Angiogenesis

Introduction Angiogenesis refers to the birth of new microvessels from existing vascular networks, which are critical for tissue regeneration, development, and repair. Physiological vascular proliferation is the development of a very regular capillary network from the originally resting endothelial cells. Tumor vascular proliferation is critical for the growth of solid tumors over a few millimeters in diameter. It refers to the formation of new blood vessels by sprouting or nesting from the original blood vessels by the proliferation and migration of endothelial cells. It is regulated by a series of stimuli and inhibitors.

Cause

Causes of vascular hyperplasia

Refers to the proliferation and migration of endothelial cells, the formation of new blood vessels from the original blood vessels by budding or nesting. It is regulated by a series of stimulation and inhibitory factors.

Congenital vein wall weakness and poor venous valve structure are the main causes of the disease. Heavy physical labor, prolonged standing and increased abdominal pressure caused by various reasons can cause the valve to withstand excessive venous pressure. In the case of poor valve structure, the valve may be incompletely closed, resulting in blood reflux, due to superficial veins. The muscle wall of the wall is thin and there is no connective tissue around. The blood reflux can cause the vein to grow thicker and the varicose veins appear. Due to the increase of the venous pressure of the lower limb, a large number of capillary proliferation and permeability can be increased in the foot and the pigment is produced. Calcination and lipid hardening. The accumulation of fibrinogen, which hinders the exchange of capillaries with surrounding tissues, can lead to nutritional changes in the skin and subcutaneous tissue.

an examination

Related inspection

Capillary resistance test CT angiography

Examination of vascular proliferation

Clinical manifestations: ischemia, hypoxia, vascular dysfunction, scars, surgical mouth repair, and abnormal proliferation of tumor blood supply.

Differential diagnosis

According to clinical manifestations, combined with histopathology can be diagnosed.

Clinical manifestations: ischemia, hypoxia, vascular dysfunction, scars, surgical mouth repair, and abnormal proliferation of tumor blood supply.

Histopathology: Atypical angiogenesis is seen in the dermis. The small capillary lumen is composed of a number of large and prominent columnar endothelial cells arranged in a layer, evenly visible in the bilayer. There are many nuclei in the interstitial space between the blood vessels, which are atypical, occasionally multinucleated cells. In the matrix, red blood cell extravasation is seen. For multiple soft auburn pimples. The diameter is only a few millimeters, and the number ranges from 2 to 30. It's good to face. Can naturally fade.

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