Vasculitis

Introduction Vasculitis is the infiltration of inflammatory cells around the blood vessel wall and blood vessels, accompanied by vascular damage, including cellulose deposition, collagen fiber degeneration, endothelial cells and myocyte necrosis, also known as vasculitis. The pathogenic factors directly affect the vascular wall are primary vasculitis. The vascular inflammation produces certain clinical symptoms and signs for vasculitis. The adjacent inflammatory lesions affect the vascular wall and are secondary vessels. inflammation. A few causes are more clear, such as serum diseases, drug allergies and infections. Hepatitis B virus has been shown to be the cause of a variety of vasculitis. Chinese cytomegalovirus, herpes simplex virus, etc. can cause vasculitis.

Cause

Cause of vasculitis

Most of the causes are too difficult and unclear. A few causes have been more clear last year, such as serum drug countless drug allergies and infection with hepatitis B virus including cellulose deposition, collagen fiber degeneration, endothelial cells and myocyte necrosis, have been confirmed to be a variety of vasculitis comparison The cause is further found that cytomegalovirus, herpes simplex virus, and adult T-cell leukemia virus can cause vasculitis.

an examination

Related inspection

General radiography

Auxiliary inspection

Hematuria, platelet count and suspected blood time, erythrocyte sedimentation rate, immunoglobulin, circulating immune complex, C2, C3 and C4, CH50 rheumatoid factor, antinuclear factor, protein electrophoresis, fibrinogen determination and HBsHg examination, etc. Angiography, Doppler ultrasonography, and X-ray examination should be performed as needed.

Differential diagnosis

Vasculitis confusing symptoms

(1) allergic purpura: occurs in children and adolescents, mostly in the lower extremities with ecchymosis, siltation is the most common skin lesions, may be associated with joint pain.

Platelets are normal, urine can have proteinuria and hematuria, and occasionally gastrointestinal bleeding symptoms.

(2) papular necrotizing tuberculosis rash: more common in young women, near the joints of the limbs or hips, scattered central necrotic solid papules, leaving atrophic scars after the recovery, tuberculin test is strongly positive, histopathology has tuberculosis tissue performance .

(3) skin-type nodular polyarteritis: mostly in the lower limbs, there are subcutaneous nodules distributed along the small arteries, conscious pain and obvious tenderness, skin histopathological manifestations of arteritis and small arterial necrosis.

(4) should also be differentiated from hyperglobulinemia, acute acne-like lichen-like pityriasis and nodular vasculitis.

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