Ahidrotic duct keratinocyte differentiation

Introduction Gastrointestinal cancer, colon and rectal cancer is the second most common primary tumor and is also the most common visceral tumor that metastasizes to the skin. Most occur in the rectum, accounting for 11% to 19% of male skin metastatic cancer, and 1.3% to 9% of women. Colorectal cancer is usually found before skin metastasis. Skin metastases from the gallbladder and bile ducts can be seen when the primary tumor is found, or late after the primary tumor is removed. Skin metastases from the stomach and pancreas usually occur before the discovery of the primary tumor, usually from the abdominal wall, perineum and umbilicus. There are very few inflammatory cell infiltration around the tumor cells, and there is no differentiation of the keratin membrane of the sweat gland duct. It is often a feature of metastatic skin tumors.

Cause

The etiology is still unknown. The distribution of tumor thrombosis in the skin or subcutaneous fat vessels or lymphatic vessels is narrow and trapezoidal at the bottom. It is generally not connected with the epidermis. There is very little inflammatory cell infiltration around the tumor cells. Membrane differentiation, etc., is often a feature of metastatic skin tumors.

an examination

Related inspection

Gastric juice-associated antigen

Differential diagnosis

Differential diagnosis: should be differentiated from suppurative sweat gland inflammation, scleroderma.

Suppurative sweat gland inflammation: Suppurative sweat gland inflammation is a chronic suppurative inflammation of the apocrine sweat gland, which occurs mainly in the underarms, external genitalia, and perianal area. It occurs mostly in young and middle-aged women and may be related to the development of female sweat glands. The pathogens are mainly Staphylococcus aureus, and may also be infected with Streptococcus pyogenes and other Gram-negative bacteria.

Scleroderma: Scleroderma is a systemic connective tissue disease. The cause is related to genetic and immune abnormalities, and occurs mostly in women of childbearing age. Clinically characterized by localized or diffuse skin thickening and fibrosis, and involving connective tissue diseases of the internal organs such as heart, lung, kidney, and digestive tract.

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