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Poor microcirculation perfusion

Introduction
Cause
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Diagnosis

Introduction

Introduction Circulatory disorders are morphological abnormalities and dysfunctions of blood vessels and blood flow that occur at the level of microcirculation. Microcirculatory disorders can lead to a significant reduction in tissue blood perfusion, resulting in a series of ischemic and hypoxic lesions, which can cause organ dysfunction or failure in severe cases. Microcirculatory disorders often occur in processes such as trauma, inflammation, edema, shock, tumor, hyperinjury, rejection of tissue and organ transplantation, and diseases associated with these. In recent years, Chinese scholars have experienced epidemic cerebrospinal meninges. Severe infectious diseases such as inflammation and poisoning dysentery have been carefully observed in the laboratory. The acute microcirculatory disturbance caused by arteriolar spasm is the main pathological change in the early stage of the disease, and it causes a series of serious diseases. The basis of the shape. The pathological changes in microcirculatory disorders are mainly changes in microvessels, microvascular flow and microvascular circumference.

Cause

Cause

Reasons for poor microcirculation perfusion:

Such as bacteria, viruses, physical and chemical factors, as well as secondary changes such as ischemia and hypoxia, acidosis, etc. can act on the microvascular wall, causing direct or indirect damage. At this time, the earliest reaction is the swelling and separation of the vascular endothelium. In severe cases, the endothelial cells can die into "herpes"-like processes, and even the endothelial cells fall off, resulting in the narrowing of the microvascular lumen and the micro-blood flow. Kind of obstacle. The above lesions cause severe damage to the integrity and extensibility of the microvascular wall, resulting in prolongation, bending, and local expansion of the microvessels to form microangioma. These lesions can further slow the blood flow, increase the stasis, and form a pathological tiny blood pool in the lesion. Here, the accumulation of platelets, white blood cells or red blood cells is most likely to occur, and the micro-blood flow is "sludged", which promotes local or systemic disseminated intravascular coagulation. In addition, necrosis of microvascular wall endothelial cells, collagen under endothelial cells Exposure, plasma contact with collagen, etc., can promote the occurrence of local or systemic play intravascular coagulation. At the same time as the above changes, the effects of histamine, 5-oxamine, stimuli, local acidosis, and increased osmotic pressure can directly or indirectly cause the two adjacent endothelial cells on the capillary wall. The cracks in the tight joints are enlarged, resulting in a significant increase in permeability. The destruction of the capillary basement membrane further increases the degree of permeability increase. In addition, vasodilatation and micro-blood stasis are also factors that promote or exacerbate the microvascular permeability. Increased microvascular permeability is most pronounced in capillary venous and venules (see "Inflammation"). The result of an increase in microvascular permeability is necessarily a large exudation of blood components to the outside of the microvessels, which may result in an effective circulating blood volume reduction and blood concentration, further aggravating microcirculatory disorders.

In recent years, diseases having abnormal changes in microvascular function and morphology have been collectively referred to as microvascular diseases.

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an examination

Related inspection

Doppler echocardiography two-dimensional echocardiography central venous pressure measurement (CVP)

Diagnosis of poor microcirculation perfusion:

Circulatory disorders are morphological abnormalities and dysfunctions of blood vessels and blood flow that occur at the level of microcirculation. Microcirculatory disorders can lead to a significant reduction in tissue blood perfusion, resulting in a series of ischemic and hypoxic lesions, which can cause organ dysfunction or failure in severe cases. Microcirculatory disorders often occur in processes such as trauma, inflammation, edema, shock, tumors, hyperaccumulation, rejection of tissue and organ transplants, and diseases associated with these.

The pathological changes in microcirculatory disorders are mainly changes in microvessels, microvascular flow and microvascular circumference.

Diagnosis

Differential diagnosis

Poor microcirculation perfusion needs to be differentiated from the following symptoms:

Intraosseous lesions: microcirculatory disorders (ischemia, congestion, disseminated intravascular coagulation) cause microcirculatory arterial blood perfusion, and bone function and metabolic disorders due to hypoxia. Mainly manifested as microvascular endothelial damage and microthrombus formation. The blood vessels of the human body are the conduits for transporting blood. It is like a big river, gradually branching and irrigating the surrounding land. It is also nurturing tissue cells around the blood vessels. As the blood passes through the large blood vessels to the tiny arterioles, it flows through the widely distributed capillary network and then merges into the tiny venules. Because this part of the blood vessel has a small caliber, it is invisible to the naked eye and can only be seen under a microscope, so it is called a microcirculation.

Microcirculatory disorders: Microcirculation is the blood circulation in the capillaries between the arterioles and venules, and is the most basic structural and functional unit in the circulatory system. It includes bodily fluid circulation in the arterioles, venules, capillary lymphatic vessels, and tissue ducts. Every organ in the human body, each tissue cell must provide oxygen and nutrients from the microcirculation, transfer energy, exchange information, and eliminate carbon dioxide and metabolic waste. Once the microcirculation of the human body is impeded, its corresponding tissue system or internal organs will be affected and unable to function normally, which will easily lead to aging, immune function disorder and disease.