Papillary hyperplasia

Introduction Changes in papillary hyperplasia are asymptomatic nodular or papillary mucosal lesions, common in squamous epithelium, squamous epithelium protruding to the surface to grow papillary, excessive incomplete keratinization, nipple center containing vessels Loose connective tissue. Squamous epithelial hyperplasia is a vulvar disease in which genital itching is the main symptom. The genital itching of unknown cause can also lead to squamous epithelial hyperplasia after long-term grasping and rubbing. Although other diseases such as Candida vaginal vulvitis can cause changes in the squamous epithelial hyperplasia of the vulva, but because of its clear cause, after treatment for its primary disease, it can be quickly cured, so it is not in the scope of this disease.

Cause

Squamous epithelial hypertrophic lesions caused by human papillomavirus infection. There are many subtypes of HPV, and HPV6, 11, 16, and 18 are mainly related to genital warts. Reported at home and abroad, the incidence of vulvar condyloma acuminata has increased significantly, and it has become a common female sexually transmitted disease. HPV mainly infects squamous epithelium, genital condyloma acuminata is about 50%-70% accompanied by condyloma acuminata of the vagina and cervix, and is easy to be associated with various sexually transmitted diseases such as gonorrhea, trichomoniasis, Candida albicans, chlamydia, syphilis The spirals coexist. Warm, moist vulvar skin is prone to HPV growth; gestation, diabetes, and systemic diseases affecting cellular immunity, genital warts grow rapidly and are difficult to control. A small number of patients with genital warts can resolve spontaneously, but the mechanism is unknown. In addition to causing condyloma acuminata in the genital tract, HPV may also be associated with precancerous lesions of the genital tumor. In particular, HPV16 and 18 are more closely related to vulvar cancer and cervical cancer.

an examination

Related inspection

Chest B super breast palpation mammography X-ray examination cervical mucus examination general radiography

The disease is most common in the face, scalp, trunk, upper limbs, but can also occur anywhere on the body surface. The early damage of ichthyosis is a small, flat, clear-cut patch with a smooth or slightly papillary surface, pale yellowish brown or brownish brown. Later, the damage gradually increases, and the surface is more papillary-like, which can form a layer of oily thick sputum. Pigmentation can be very significant. The color of the old damage varies greatly, and it can be in the skin color or light brown or even dark brown or even black. The follicular horn plug is one of the important features, sometimes even a small early rash, which has been clearly seen, and the larger lesion of the sacral surface is polymerized by many small and flat papillary lesions. The crusting is very thick and the surface is papilloma-like after gently peeling off the surface of the skin. Although the damage surface is mostly oily, there are many damages to the surface that are dry and warty. If the superficial is damaged, it is like sticking to the epidermis.

Differential diagnosis

Some early lesions appear to be flattened, and keratinized lesions at the exposed site are easily confused with senile keratosis (or solar keratosis); deep pigment damage should be distinguished from sputum cell sputum. The inflammatory or irritated damage of ichthyosis may be similar to basal cell tumor or squamous cell carcinoma or malignant melanoma. At this time, biopsy or postoperative biopsy or pathological examination is needed for identification.

(a) Flat wet warts: for the expression of flat, moist pimples, often fused, the base is not narrow, can find syphilis, syphilis serological positive.

(2) Female yin and pseudo-hypertension: also known as female genital genital warts like pimples, more common in young adults. The rash is located on the inner side of the labia minora on both sides. It is a fish-like or polypoid papule that does not fuse in the cluster. It has a grainy or soft feeling, is reddish, moist, generally has no symptoms, and some has mild itching. .

(3) Penile beaded papules: more common in young adults, pearly translucent papules in the coronal sulcus, white, yellowish or red, conical, globular or irregular, arranged in a row or rows along the coronary sulcus, Even wrapped around a circle, no obvious symptoms.

(4) Bowen-like papulosis: The rash is often composed of multiple pigmented papules, which can also appear as a single, scattered or clustered tendency, arranged in a line or ring shape, which can be fused into plaques and develop slowly (months) Or years), the disease is orthotopic squamous cell carcinoma, or developed from genital warts. There are a lot of women in this disease, and the distribution is mainly in the size of the labia and anus.

(5) Sebaceous gland ectopic disease: The papules are in the mucous membrane, and there is no overlapping growth, mostly yellowish.

(6) Increased sebaceous glands : yellowish papules, no pedicle, no spines, no overlap, no fusion.

(7) Para-glandular hyperplasia: The skin of the foreskin ligament is arranged in pairs on either side of the skin or reddish papules, and some surfaces may be slightly spinous. The base of the papule is not narrow, the miliary or needle is large, and there is no obvious symptoms.

(8) Infectious soft palate: a single, non-fused, skin-colored hemispherical papule with a smooth surrounding and a central umbilical recess that can be squeezed out of the soft palate.

The material in this site is intended to be of general informational use and is not intended to constitute medical advice, probable diagnosis, or recommended treatments.