Elevated corticosteroids

Introduction Elevated corticosteroids: a class of steroidal compounds synthesized and secreted by the adrenal cortex whose primary function is to regulate water-salt metabolism and glucose metabolism in animals. Corticosteroids have too many serious adverse reactions. The adverse reactions of corticosteroids include: cortical hyperfunction, steroid diabetes, muscle atrophy and osteoporosis, induce and aggravate infection, induce and aggravate ulcers, induce mental symptoms, and develop eye diseases. Teratogenicity, inappropriate withdrawal of the drug may also have symptoms such as insufficient cortical function, hormone withdrawal syndrome and symptom rebound.

Cause

(1) Stimulate hepatic gluconeogenesis: increase the activity of hepatic gluconeogenesis key enzymes, glucose-6-phosphatase and phosphoenolpyruvate carboxykinase (PEPCK), promote the decomposition of muscle protein and release amino acids, and release fat. Free fatty acids, increased liver gluconeogenesis and other substrates.

(2) Inhibition of glucose uptake and utilization by peripheral tissues: High concentrations of glucocorticoids not only inhibit the binding of insulin to its receptor, but also impair the role of the glucose transport system in peripheral tissue receptors.

(3) Increased hepatic glycogen synthesis: This effect of glucocorticoids is achieved by increasing the activity of hepatic glycogen synthase.

(4) "Allow" and "synergistic" effects on the glycosidic effects of glucagon, adrenaline and growth hormone.

an examination

Related inspection

Blood routine urinary adrenaline urinary norepinephrine

Severe abdominal pain, torticollis, ear swelling, perioral sensation, lactation inhibition, skin pigmentation, should be checked in the endocrinology department of a regular hospital to determine what causes, such as thyroid hormone, adrenal hormones, etc. Department of MRI examination, etc.

Differential diagnosis

High blood sugar levels are caused by insufficient insulin in the body, insufficient blood sugar control, or the inability to use insulin effectively.

Many factors can lead to high blood sugar, high blood sugar can also occur in the following situations: excessive intake of sugar; insufficient physical activity; the impact of certain diseases, such as colds or flu; external pressures, such as family conflicts, between friends, colleagues Problems can cause mood swings that cause blood sugar to rise. Clinical manifestations of hyperglycemia include: elevated blood sugar, elevated urine sugar, polyuria, and polydipsia.

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