Hard lumps on the skin

Introduction The symptoms of leukemia are mainly related to the destruction of hematopoietic function in the bone marrow. Because white blood cells have the function of permeation into tissues, some of the symptoms are also related to this characteristic. The appearance of lumps on the skin is a symptom caused by the permeation of blood cancer cells. Leukemia is a malignant disease of hematopoietic tissue, also known as "blood cancer." Leukemia accounts for about 5% of total cancer incidence, 2% of adult cancer, and more than 30% of childhood cancer. The main manifestations are the proliferation and infiltration of leukemia cells. Non-specific lesions are hemorrhage and tissue malnutrition and necrosis, secondary infections, and the like.

Cause

Leukemia is a progressive, uncontrolled, abnormal proliferation of leukocytes and their naive cells (ie, leukemia cells) in bone marrow or other hematopoietic tissues. Infiltrating various tissues, producing different symptoms; normal blood cell production is reduced, and the surrounding white blood cells have qualitative and quantitative changes. Therefore, leukemia is a malignant tumor of the hematopoietic system.

The main manifestations are the proliferation and infiltration of leukemia cells. Non-specific lesions are hemorrhage and tissue malnutrition and necrosis, secondary infections, and the like. The proliferation and infiltration of leukemia cells mainly occur in bone marrow and other hematopoietic tissues, and can also occur in other tissues of the body, resulting in a significant decrease in normal erythroid cells and megakaryocytes. In the bone marrow, some leukemia cells may be active or extremely active, but may be grayish red or yellowish green. Lymphoid tissue can also be infiltrated by leukemia cells, and lymph nodes are enlarged later. 50% to 80% of leukemia patients have significant changes in central nervous system leukemia. Commonly known as intravascular leukocyte stagnation, perivascular leukocyte proliferation. Other organs most frequently suffering from leukemia infiltration are the kidney, lung, heart and thymus, testis and the like.

an examination

Related inspection

Blood routine albumin (A, Alb) serum total protein (TP, TP0)

Leukemia is a disease of the bone marrow, so a bone marrow puncture and bone marrow biopsy are needed to confirm the diagnosis. In order to further confirm the type of leukemia, additional special examinations are needed to accurately classify leukemia and give the most appropriate treatment. These special tests include: cell biochemical special staining, flow cytometry, and chromosome examination.

Differential diagnosis

It should be differentiated from aplastic anemia, myelodysplastic syndrome, infectious mononucleosis, primary thrombocytopenic purpura and leukemia-like reactions.

Leukemia is a disease of the bone marrow, so a bone marrow puncture and bone marrow biopsy are needed to confirm the diagnosis. In order to further confirm the type of leukemia, additional special examinations are needed to accurately classify leukemia and give the most appropriate treatment. These special tests include: cell biochemical special staining, flow cytometry, and chromosome examination.

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