Adhesive leukoplakia

Introduction Adhesive leukoplakia is a symptom of the clinical manifestations of chronic cutaneous mucosal candidiasis. Chronic mucocutaneous candidiasis is a bacterial immunodeficiency disease of persistent Candida infections of the skin, mucous membranes, hair and nails. This disease, unlike other cellular immunodeficiency diseases, only responds to Candida albicans and a small number of antigen-related fungi, but is immune to viruses, bacteria and other microorganisms. This disease is a syndrome of some diseases, which can be combined with various endocrine organ dysfunction, tumors and other chronic debilitating diseases, and can also occur during the application of immunosuppressive agents.

Cause

The cause is Candida infection, which is an autosomal recessive disease.

an examination

Related inspection

Laboratory examination of urinary immunoglobulin fungal infections

It occurs mostly in women and can occur at any age. Infants often have persistent thrush. Light lesions of the lesion only affect the nails, and severe skin, mucous membranes and hair are involved. The skin has scaly and eczema; the mucosa has Candida adhesion leukoplakia; the nail is malnourished or hyperkeratotic. Chronic esophageal candidiasis can cause stenosis and can be associated with sinus and lung infections. Children with growth and development disorders. Older people are generally lighter.

Another type is juvenile familial polyendocrine syndrome with sclerotia, in addition to mild to moderate candidiasis, usually hypothyroidism, hypoparathyroidism, Addison disease or several years after the onset of Candida diabetes. Usually, autoantibodies to the affected endocrine organs can be found. In addition, ovarian dysfunction, pernicious anemia, alopecia and chronic active hepatitis can be complicated.

It can be diagnosed according to clinical and laboratory tests.

Differential diagnosis

Conjunctival dry spots: Bi-spotted spots, also known as conjunctival dry spots, vitamin A deficiency. Children lack the most important clinical signs of vitamin A. The patient is close to the cornea and the outside of the conjunctiva due to dryness and wrinkles, and the keratinized epithelium accumulates, forming white spots of varying sizes resembling foam.

Mucosal leukoplakia: Oral leukoplakia is the most common and important oral keratosis abnormality. It is an idiopathic, persistent leukoplakia that needs to be diagnosed in combination with histopathology.

Forehead leukoplakia: A typical feature of plaque albinism is frontal leukoplakia, 80% to 90% may be associated with frontal white hair, triangular or rhomboid, symmetrical, located in the center of the forehead or slightly to one side, can be extended down to the nose Root.

Avascular atrophic leukoplakia: 10% to 30% of patients with systemic lupus erythematosus can see reticular leukoplakia, which is a manifestation of small vessel inflammation and circulatory disorders. It is a narrowing of the small arteries of the limbs, and the venules are dilated and on the surface of the skin. Reticulated, dendritic erythema, purple bluish, often appear in cold conditions, and may be related to cryoglobulinemia and anti-cardiolipin antibodies. Occurs in the thighs, calves, hands, back of the feet, elbows, knees, if there is necrotizing vasculitis, often accompanied by purple spots, gangrene, ulcers. If the vascular disease is severe, skin lesions of the leukoplakia vasculitis may occur, manifested as blemishes accompanied by painful ulcers, and the ulcers healed to form atrophic scars with hypopigmentation and telangiectasia, ie, atrophic leukoplakia. It occurs mostly in women and can occur at any age. Infants often have persistent thrush. Light lesions of the lesion only affect the nails, and severe skin, mucous membranes and hair are involved. The skin has scaly and eczema; the mucosa has Candida adhesion leukoplakia; the nail is malnourished or hyperkeratotic. Chronic esophageal candidiasis can cause stenosis and can be associated with sinus and lung infections. Children with growth and development disorders. Older people are generally lighter.

Another type is juvenile familial polyendocrine syndrome with sclerotia, in addition to mild to moderate candidiasis, usually hypothyroidism, hypoparathyroidism, Addison disease or several years after the onset of Candida diabetes. Usually, autoantibodies to the affected endocrine organs can be found. In addition, ovarian dysfunction, pernicious anemia, alopecia and chronic active hepatitis can be complicated.

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