Diffuse mesangial sclerosis

Introduction Diffuse mesangial hyperplasia or sclerosis is one of the diagnostic criteria for purpuric nephritis. Anaphylatic purpura nephritis refers to kidney damage caused by allergic purpura. The cause can be allergic reactions caused by infections such as bacteria, viruses and parasites, or allergies to certain drugs, foods, etc., or plant pollen. , insect bites, cold stimuli, etc. Kidney damage caused by allergic purpura. It is a diffuse or limited degenerative change in the choroid accompanied by retinal degeneration and pigmentary changes. It has a family history and different genetic forms. It is more common in the elderly but not often associated with systemic arteriosclerosis.

Cause

The cause may be an allergic reaction caused by infections such as bacteria, viruses and parasites. The sclerosis is a neurodegenerative disease, which is a progressive degeneration of the spinal cord anterior horn cells and brainstem nucleus and the brain motor cortex pyramidal cells. disease.

an examination

Related inspection

MRI examination of liver, gallbladder, pancreas and spleen: CT examination of laparoscopic liver, gallbladder and spleen

1. International Childhood Kidney Disease Research Association (1sKDC) pathological classification

I degree: a small lesion.

II degree: for mesangial hyperplasia.

III degree: (a) focal and (b) diffuse hyperplasia or sclerosis, crescent formation.

Grade IV: (a) focal and (b) diffuse mesangial hyperplasia or sclerosis, 50% to 75% of crescent formation.

V degrees: (a) focal and b (a) diffuse mesangial hyperplasia or sclerosis, crescent formation > 75%.

VI degree: membranous proliferative lesions.

2. World Health Organization (WHO) pathological grading

I: Including small lesions, small lesions with focal segmental significance, focal proliferative glomerulonephritis mild.

II: Mild diffuse proliferative glomerulonephritis, diffuse proliferative glomerulonephritis mildly with focal segmental significance.

III: including moderate proliferative glomerulonephritis, moderate diffuse proliferative glomerulonephritis.

IV: including diffuse proliferative glomerulonephritis, severe end-stage kidney.

Differential diagnosis

When purpuric nephritis rash has subsided, it needs to be differentiated from acute nephritis; if it is accompanied by pulmonary hemorrhage and hemoptysis, it should be differentiated from Goodpasture syndrome; it should be differentiated from lupus nephritis and primary systemic vasculitis.

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