Diffuse periosteal thickening

Introduction Diffuse periosteal thickening is one of the symptoms of periosteal hyperplasia. Perioid hyperplasia (pachydermoperiostosis) is divided into primary and secondary. The primary is autosomal dominant. Secondary is often triggered by liver, lung and digestive tract diseases or malignant tumors. This disease is more common in men.

Cause

Often caused by liver, lung and digestive tract diseases or malignant tumors.

The disease has two types of primary and secondary

1. Primary: more common in men, often soon after puberty. Facial, forehead, and head skin hypertrophy, wrinkled forehead changes are particularly prominent, and the amount of horizontal stripes is deepened. The head is back-shaped cranium, especially the upper eyelids are thick and slack, the ears and lips are also thicker, the skin of the hands and feet is also hypertrophied, the bones of the limbs and the phalanx are hypertrophy, the fingers and toes are sick, and the knee joint effusion . The patient has pain in his limbs and is awkward

2. Secondary: After the middle-aged disease, the skin changes are not significant in women. The bone lesions are obvious and fast, and the pain is conscious. After the primary disease is alleviated, the bone and skin lesions are alleviated.

an examination

Related inspection

Skeletal examination bone palpation

Diagnostic points

First, the primary

1. Occurs after puberty.

2. The forehead and cheek skin are obviously thickened, wrinkles appear, the scalp is thickened to form the scalp, the skin of the hands and feet is thickened, no wrinkles, often sweaty; often accompanied by obvious clubbing.

3. The extremities are thickened in the shape of a periosteum, and the sacral and knee joints are swollen.

4. Histopathology shows that long bone is predominantly proliferative periostitis with diffuse irregular periosteal thickening.

5. Can be accompanied by mental retardation.

6. The disease can be stable and not continue to develop 5 to 10 years after the onset of illness.

Second, secondary

1. Middle-aged and elderly patients.

2. The periosteal thickening is fast and obvious, often painful, but the skin lesions are lighter.

3. Histopathology is the same as primary.

Differential diagnosis

This symptom should be differentiated from the symptoms of acromegaly and thyroid acromegaly.

Diagnostic points

First, the primary

1. Occurs after puberty.

2. The forehead and cheek skin are obviously thickened, wrinkles appear, the scalp is thickened to form the scalp, the skin of the hands and feet is thickened, no wrinkles, often sweaty; often accompanied by obvious clubbing.

3. The extremities are thickened in the shape of a periosteum, and the sacral and knee joints are swollen.

4. Histopathology shows that long bone is predominantly proliferative periostitis with diffuse irregular periosteal thickening.

5. Can be accompanied by mental retardation.

6. The disease can be stable and not continue to develop 5 to 10 years after the onset of illness.

Second, secondary

1. Middle-aged and elderly patients.

2. The periosteal thickening is fast and obvious, often painful, but the skin lesions are lighter.

3. Histopathology is the same as primary.

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