Masculine

Introduction Ovarian masculinizing tumors are ovarian tumors that originate from specific cord stroma. The reason why it is called ovarian masculinizing tumor is named because it secretes male hormone and has masculinizing effect.

Cause

(1) Ovarian masculinizing tumor tissue may come from:

1. The sex gonads are the egg testes.

2. Residual ovarian primordial testicular cells that secrete androgen.

3. Granulosa cell tumors.

4. Teratoma.

5. Mixed mesodermal tumors containing Müllerian epithelium and testicular derivatives in the ovarian stroma.

(2) The ovarian masculinizing tumor is characterized by the differentiation of tumor cells into the testis, which is similar to the testicular tissue at different stages. The tumor consists of tubular structures and interstitial cells formed by supporting cells. If interstitial cells are predominant, it will have a significant masculine effect. If the support cells are predominant, feminization symptoms can occur, and some tumors produce both androgen and estrogen.

an examination

Related inspection

Neutrophil nuclear sputum corpuscle ovarian function test ovarian examination sex observation plasma cortisol

[Clinical manifestations of ovarian male tumors]

(A) support - stromal cell tumor: the typical clinical symptoms are female sexual characteristics reduction, adult women first manifested amenorrhea, breast and uterus atrophy, subcutaneous fat disappeared and body shape changes, and then masculine phenomenon showed hairy, acne The clitoris is hypertrophy, the tone is low, etc. These clinical manifestations are mainly caused by swelling and pain to secrete male hormones, masculinization and hairy phenomenon, and the symptoms develop slowly. Hairy is due to the secretion of testosterone by the tumor, so blood testosterone is often elevated, but more than half of the cases of 24-hour urine 17-ketone is normal.

(B) portal cell tumor: its main clinical manifestations are masculine, alopecia, men's body and face, hairy and clitoris increased are rare. Most are benign, and very few are vicious. Tumor cells exhibit a high degree of atypicality and abnormality when malignant.

(C) lipid cell tumor: clinically, most patients have obvious masculinization symptoms, but also hairy phenomenon occasionally showing symptoms of estrogen increase such as menorrhagia, with endometrial hyperplasia or uterine body cancer.

[Ovarian masculinizing tumor diagnosis]

According to the symptoms and signs of various types of tumors mentioned above, masculine tumors can be diagnosed. However, it is difficult to clearly diagnose the type of tumor before surgery.

Differential diagnosis

It is necessary to identify whether the secreted androgen is derived from an ovarian tumor or an adrenal gland disease, in which the latter 17-ketone is often elevated, and the former is normal or low. Ovarian masculinizing tumors do not respond to the dexamethasone suppression test, but if the patient is injected with 5000 U of chorionic gonadotropin, then the urinary 17-ketone or blood testosterone levels are observed, and any increase in value is expressed as ovarian masculinizing tumor.

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