Elevated follicle stimulating hormone (FSH)

Introduction The chemical structure of follicle stimulating hormone (FSH): a glycoprotein, which is formed by covalent bonding of two subunit peptide chains a and b. A hormone secreted by basal cells of the anterior pituitary gland, composed of glycoprotein. The main role is to promote follicular maturation. Human follicle stimulating hormone promotes the proliferation and differentiation of follicular granule cells and promotes the growth of the entire ovary. Acting on the testicular seminiferous tubules can promote sperm formation. Injection of FSH only increased the number of follicles and had no effect on follicular maturation. The follicle stimulating hormone releasing hormone secreted by the hypothalamus controls the secretion of follicle stimulating hormone. During the menstrual cycle, the concentration of FSH in the blood and the amount of FSH excreted daily by the urine vary with the cycle. After menopause, the amount of FSH excreted in blood and urine increased. The FSH value rises very quickly, possibly due to a decline in ovarian function.

Cause

Decreased ovarian function causes an increase in follicle stimulating hormone (FSH).

Follicle stimulating hormone (FSH) assay

[normal reference value]

Male: 2.5-15U/L.

Female: 4-20U/L; postmenopausal: >40-20OU/L.

Increased: seen in testicular seminoma, K1inefelter syndrome, Turher syndrome, primary amenorrhea, castration, adrenal cortical hormone therapy, primary hypogonadism, early anterior pituitary hyperfunction, and giant cell degenerative lung cancer With the secretion of ectopic adenoids.

an examination

Related inspection

Follicular detection of fallopian tube fluid test follicle stimulating hormone (FSH) urinary follicle stimulating hormone

Follicle stimulating hormone is a hormone synthesized and secreted by the pituitary gland. It belongs to the glycosylated protein hormone and is named for its early stimulation of the maturation of female follicles. Later studies have shown that follicle stimulating hormone is one of the most important hormones in both sexes, regulating development, growth, adolescent sexual maturity, and a range of physiological processes related to reproduction. Follicle stimulating hormone and luteinizing hormone play a crucial role in the reproductive-related physiological processes.

Follicle stimulating hormone is a glycoprotein, and the active form is a glycosylated heterodimer composed of two polypeptides, alpha and beta. Glycoprotein hormones such as luteinizing hormone, thyroid hormone, and human chorionic gonadotropin adopt a structure similar to follicle stimulating hormone. They share the same alpha subunit (containing 92 amino acid residues), while the beta subunits vary from hormone to hormone. The beta subunit of follicle stimulating hormone contains 118 amino acid residues responsible for interaction with the follicle stimulating hormone receptor. Glycosylation of follicle stimulating hormone surfaces involves trehalose, galactose, mannose, galactosamine, glucosamine, and aluminosilicate. Among them, aluminosilicate is closely related to the biological half-life of follicle stimulating hormone. The half-life of follicle stimulating hormone is 3 to 4 hours. The molecular weight of follicle stimulating hormone is about 30,000 Da.

Differential diagnosis

Increased: primary hypogonadism, ovarian or testicular dysplasia (Klinefelter syndrome, Turner syndrome), chronic alcoholism, postmenopausal and so on. Reduction: anterior pituitary dysfunction, mental anorexia, prostate cancer, sickle cell anemia, chronic wasting disease.

Normal value: male (adult) female follicular phase 0.7 ~ 2.2g / L ovulation period 1.4 ~ 3.8g / L luteal phase 0.4 ~ 2.1g / L menstrual period 0.5 ~ 2.5g / L, can be measured compared with normal values The level of follicle stimulating hormone (FSH) can be verified.

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