Skin neuroma

Introduction to cutaneous neuroma Neuromacutosis (neuromacutis) is not common, clinical manifestations can be divided into the following three types: traumatic neuroma (traumaticneuromas); multiple mucosal neuroma (multiple mucosal neuromas); isolated palisade enveloped neuroma (solitarypalisadedencapsulatedneuroma). basic knowledge The proportion of illness: 0.005% Susceptible people: no special people Mode of infection: non-infectious Complications: pheochromocytoma

Cause of cutaneous neuroma

Causes:

The cause is still unknown.

Pathogenesis

The pathogenesis is still unclear.

Skin neuroma prevention

Skin neuroma prevention first focuses on and improves those factors that are closely related to our lives, such as smoking cessation, proper diet, regular exercise, and weight loss. Appropriate exercise, enhance physical fitness and improve your disease resistance. Anyone who follows these simple and reasonable lifestyle knowledge can reduce the chance of suffering from cutaneous neuroma. Pay attention to early prevention.

Derma neuroma complications Complications pheochromocytoma neuroma

Multiple mucosal neuroma, often associated with thyroid myeloma, bilateral pheochromocytoma and diffuse gastrointestinal ganglion neuroma.

Symptoms of cutaneous neuroma Common symptoms Skin tenderness Nodules Pain nerve fibers Overgrowth Limb often has numbness on the far side

1. Traumatic neuromas caused by excessive growth of peripheral nerve fibers, which can damage pain and tenderness, cause scarring or remove distal limbs, and cause phantom limb syndrome. This disease often occurs in the finger's excess finger amputation, or usually in the clavicle of the third metatarsal space.

2. Multiple mucosal neuromas are patients with multiple mucosal neuroma syndrome. They can have a large and prominent lip and oral mucosa (lip, tongue and gums). Conjunctiva, scleral multiple neuroma, a small number of multiple neurocutaneous neuromas, usually located in the face, skin lesions are mostly soft, skin color or reddish papules and nodules, often associated with thyroid marrow cancer, bilateral pheochromocytoma And diffuse gastrointestinal ganglion neuroma.

3. Solitary palisaded encapsulated neuroma is a large, enveloped tumor, usually located on the face, with slow growth and a flesh-colored dome-shaped solid nodule, usually occurring around the mouth or nose. The disease is very similar to basal cell tumor or intradermal fistula.

Examination of cutaneous neuroma

Histopathology: traumatic neuroma, usually a well-defined nodular lesion located in the dermis or subcutaneous tissue. The tumor is wrapped by a fibrous sheath, and the distal parcel is incomplete. The regenerated fibers can infiltrate adjacent matrices, and the tumor nodules are sized. The regenerative nerve bundles of different shapes are composed of tangled tangles and are separated by chronic inflammation or granulomatous reactions of varying degrees of fibrous tissue. The palisade-like enveloped neuromas consist of densely braided bundles separated by translucent fissures. The cells in the bundle are spindle-shaped cells with the same shape and shape, with eosinophilic cytoplasm and oval or wavy nucleus. The tumor is separated from the surrounding dermis by a thin cystic structure. The tissue of multiple mucosal neuromas except the cystic wall is organized. Similar to a palisade-like enveloped neuroma.

Palisade-like enveloped neuroma and traumatic neuroma, the cells composed of S-100 protein staining positive, the peripheral nerve cells of the traumatic neuroma are positive for epithelial membrane antigen, and the palisade-like envelope neuroma only The outer membrane is positive for the epithelial membrane antigen. Silver staining and neurofilament staining show that the braided bundle contains a large number of axons in both lesions, and the common myelin formation is common, and the myelin base protein antibody can be detected. Proved with CD57 antigen.

Diagnosis and diagnosis of cutaneous neuroma

According to the clinical manifestations, the characteristics of skin lesions and histopathological features can be diagnosed.

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