Autoimmune progesterone dermatitis

Introduction to autoimmune progesterone dermatitis Autoimmuneprogesteronedermatitis is a characteristic, vesicular bullous disease of the chronic, generalized herpetic dermatitis. This disease was first reported by Shelley et al in 1964. basic knowledge The proportion of illness: 0.001% Susceptible people: women Mode of infection: non-infectious Complications: herpes-like dermatitis

Causes of autoimmune progesterone dermatitis

Cause:

May be caused by the body's own sensitivity to progesterone, patients often worsened from 1 week to 10 days before menstruation, can also use the oral 20mg progesterone 7h to stimulate the onset of skin lesions.

Pathogenesis

The pathogenesis is still unclear, and most of them are thought to be the immune response of their own progesterone.

Autoimmune progesterone dermatitis prevention

1. Increase outdoor activities, first accept low-dose ultraviolet radiation, gradually increase the amount of light, in order to gradually improve the body's ability to withstand light exposure, beware of sudden long-term intense sun exposure. If you are traveling, it is best to wear a wide-brimmed protective cap or cover with a parasol, and wear a light-colored long-sleeved shirt.

2. Wash your face with water after going home. Pay attention to the use of cold water to wash your face, do not use alkaline soap. Pay attention to moisturizing, sensitive skin people can use hospital preparations such as: silicone cream, vitamin E milk skin care.

3. Do not use cosmetics with more water-sensitive substances, such as impure Vaseline and inferior aroma skin care products.

Autoimmune progesterone dermatitis complications Complications, herpes-like dermatitis

Generally no complications.

Autoimmune progesterone dermatitis symptoms Common symptoms Papular similar to urticaria skin... Polymorphic erythematous rash herpes herpes whistles

The damage can persist, but as women's menstrual cycle is regularly aggravated and relieved, the lesion may sometimes be urticaria-like, polymorphic erythema or herpes-like polymorphic damage. Some patients have artificial progesterone before the skin lesion occurs. Experience, some patients after the normal pregnancy, rash often occurs 5 to 10 days before menstruation, can be self-resolved after menstruation, can be re-issued before the next menstruation, some patients can have spontaneous abortion, the disease can be expressed For urticaria, generalized wheal, pruritus, and often accompanied by throat, papular urticaria or papules, eczema-like or polymorphous erythematous rash, oral ulcers, damage to the front of the humerus And a half-moon-shaped relaxing blisters on the back. The blisters are located on the basis of erythema, and the blister rupture leads to scarring and hypertrophic hypopigmentation scars.

Examination of autoimmune progesterone dermatitis

Check the items in accordance with the actual situation of the patient.

Diagnosis and diagnosis of autoimmune progesterone dermatitis

According to the clinical manifestations of the disease and the special rules of endocrine changes, combined with the positive test of progesterone intradermal test can determine the diagnosis.

1. According to the patient's onset and clinical manifestations 5 to 10 days before menstruation, the possibility of the disease should be considered.

2. The diagnosis can be confirmed by intradermal test with 0.01ml progesterone suspension (50mg/ml). The skin test can be detected quickly (within 30min) or late (24~96h).

3. Intramuscular injection or oral progesterone can induce this disease.

Generally not confused with other diseases.

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