Metastatic skin calcification

Introduction to metastatic skin calcification Calcinosiscutis is a disease caused by the deposition of insoluble calcium salts (mainly undetermined calcium phosphate or small amounts of calcium carbonate) in the skin or subcutaneous tissue. It can be divided into metastatic skin calcification, malnutrition calcification and special hair. Type 3 such as sexual calcification. basic knowledge The proportion of illness: 0.0055% Susceptible people: no specific population Mode of infection: non-infectious Complications: idiopathic skin calcification

Causes of metastatic skin calcification

(1) Causes of the disease

As a result of hypercalcemia or hyperphosphatemia, the causes of hypercalcemia are:

1. Primary hyperparathyroidism.

2. Ingest too much vitamin D.

3. Osteomyelitis or cancer metastasis causes extensive destruction of bone, chronic renal failure, decreased function of renal phosphorus removal, and hyperphosphatemia with compensatory serum calcium concentration may occur.

(two) pathogenesis

Decreased serum calcium levels can stimulate the secretion of parathyroid glands, leading to secondary hyperparathyroidism, reabsorption of calcium and phosphorus from the bone, excessive mineral elimination of the bone can cause malnutrition and metastatic calcium deposition.

Metastatic skin calcification prevention

Treat the underlying disease as much as possible and not abuse the vitamin D preparation.

Metastatic skin calcification complications Complications idiopathic skin calcification

Calcium can occur in or around the blood vessels in the deep or subcutaneous tissue of the dermis, resulting in occlusion of these vessels and embolic ulcers.

Symptoms of metastatic skin calcification common symptoms calcified nodules subcutaneous nodules calcified papules

Occurred in renal hyperparathyroidism and bone dystrophy, damage to the hard white papules, arranged in a linear or symmetric distribution of nodular plaques, from the rash and nodules can squeeze out white granular substances Mainly for the subcutaneous nodules near the large joints, occasionally quite large, with the increase of nodules, there may be fluctuations, calcium deposition may occur in or around the deep or subcutaneous tissue, resulting in occlusion and embolization of these vessels Sexual ulcers, especially in the calf.

Examination of metastatic skin calcification

Histopathology: The subcutaneous tissue is generally massive calcium deposits, usually granular and small deposits on the inner side of the dermis, infarct necrosis area, calcification of the affected vessel wall, and calcium deposits stained dark blue when stained with hematoxylin Confirmed diagnosis.

Diagnosis and differentiation of metastatic skin calcification

According to the clinical manifestations, the characteristics of skin lesions and histopathological features can be diagnosed.

Generally not confused with other diseases.

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