Zollinger-Ellison syndrome

Introduction to Zhuo-Ehrlich syndrome Zhuo-Ehrlich syndrome refers to a tumor caused by gastric sinus G cell hyperplasia or secretion of gastrin. It is characterized by hypergastrinemia with massive gastric acid secretion and multiple upper gastrointestinal tract, refractory digestive ulcer. basic knowledge The proportion of illness: the incidence rate is about 0.005% - 0.008% Susceptible people: adults with irregular diet Mode of infection: non-infectious Complications: Hyperparathyroidism Diabetes

The cause of Zhuo-Ehrlich syndrome

Gastric sinus G cell proliferation or secretion of gastrin tumors.

Zhuo-Ehrlich syndrome prevention

a long-term mental stress

Long-term mental stress affects the autonomic nervous system through the cerebral cortex, causing vasoconstriction of the gastric mucosa, gastric dysfunction, excessive secretion of gastric acid and pepsin, leading to gastritis and ulceration. Clinically, long-term anxiety and depression, the incidence of gastric ulcer and duodenal ulcer is significantly increased.

Two rings are overworked

No matter whether you are engaged in physical labor or mental work, you should not be overworked. Otherwise, it will cause insufficient blood supply to the digestive organs and disorder of gastric mucosal secretion, which will lead to various stomach diseases.

Three-term diet, hunger and malnutrition

The hunger and satiety is very harmful to the stomach. When the hunger is empty, the gastric acid and pepsin secreted by the gastric mucosa can easily damage the stomach wall, leading to acute or chronic gastritis or ulceration. Overeating can cause excessive expansion of the stomach wall, and food stays in the stomach for too long, which is also likely to cause acute and chronic gastritis or ulcers, and even acute gastric dilatation and gastric perforation.

Four rings and alcoholism

Alcohol can cause congestion and edema in the gastric mucosa, and even smash and form an ulcer. Long-term drinking also damages the liver, causing alcoholic cirrhosis. The occurrence of pancreatitis is also related to alcoholism, which in turn increases the damage to the stomach.

Five Rings

Smoking causes vasoconstriction of the gastric mucosa, which reduces the synthesis of prostaglandins in the gastric mucosa. Prostaglandins are a protective factor of the gastric mucosa, and its reduction causes damage to the gastric mucosa. Smoking also stimulates the secretion of gastric acid and pepsin, so smoking sputum is an important cause of various stomach diseases.

Liujie strong tea coffee

Strong tea and coffee are the hub

The agent can cause congestion, secretion dysfunction, and mucosal barrier destruction of the gastric mucosa through nerve reflex and direct influence, and promote ulcer disease. In addition, attention should be paid to moderate consumption of foods that are highly irritating to the stomach.

The Seven Precepts eat and devour

Chewing slowly is beneficial to the digestion of food. When eating, it is swallowed. If the food is not fully chewed, it will increase the burden on the stomach. The study also found that the secretion of saliva increased when chewing slowly, in the role of protecting the gastric mucosa, can avoid damage to the gastric mucosa caused by bad stimuli.

Ba Jie sleeps forward food

Sleeping food not only affects sleep, but also stimulates gastric acid secretion and easily induces ulcers.

Nine precepts do not talk about hygiene

It has been identified that Helicobacter pylori infection is the culprit in the pathogenesis of gastritis, ulcers and stomach cancer. It can be transmitted through tableware, toothbrushes, kissing and the like. Therefore, pay attention to hygiene, without the use of other people's tableware, dental appliances, can prevent Helicobacter pylori infection, which can prevent a variety of stomach diseases.

Ten Commander Drugs

Many drugs can damage the gastric mucosa after a long time, leading to erosive gastritis and hemorrhagic gastritis and gastric ulcer. Among them, there are three commonly used drugs that can damage the gastric mucosa: one is antipyretic analgesics such as aspirin, phenylbutazone, indomethacin, etc.; the other is hormonal drugs such as prednisone and dexamethasone; It is an antibacterial drug such as erythromycin. Be careful to use these drugs in strict accordance with the doctor's advice to avoid damage to the stomach.

Zhuo-Ehrlich syndrome complications Complications hyperparathyroidism

Associated with multiple endocrine neoplasia, such as hyperparathyroidism, diabetes and so on.

Symptoms of Zhuo-Ehrlich Syndrome Common Symptoms Diabetes watery stools fatigue abdominal pain diarrhea parathyroid function hyperthyroidism tenderness

Peptic ulcer symptoms are the most common, and the response to the treatment of ulcer drugs is poor. After the ulcer is removed from the stomach, the anastomotic ulcer, bleeding and perforation, diarrhea, drainage or lipid diarrhea, often accompanied by abdominal pain, multiple Endocrine neoplasia manifestations, such as hyperparathyroidism, diabetes and so on.

Physical examination found:

Abdominal tenderness, fatigue, endocrine tumor signs.

Examination of Zhuo-Ehrlich syndrome

Gastric juice, gastric acid determination: total amount of gastric juice at 12 hours at night > 1000 ml, about 66-90% of patients with basic gastric acid > 15 mmol / hour, about 50-67% of patients BAO / MAO > 60%.

Serum gastrin assay: 1/3 of patients often reach more than 1000pg / ml, about 2 / 3 patients at 100-1000pg / L.

Secretin or calcium challenge test: If the test is 1-2 times before the experiment or the absolute value is >500pg/ml, it is suggested to be gastrinoma.

Gastroscope, X-ray barium meal examination: ulcers can be found, mucosal folds, hypertrophy, gastric juice, etc.

Tumor localization: B-ultrasound, CT, MRI, angiography, etc. can be used.

Diagnosis and identification of Zhuo-Ehrlich syndrome

diagnosis

According to the medical history, clinical manifestations and laboratory data is not difficult to make a diagnosis.

Differential diagnosis

Identification of diseases such as duodenal ulcer, pernicious anemia, and non-gastrin-induced ulcerated islet cell tumor.

The material in this site is intended to be of general informational use and is not intended to constitute medical advice, probable diagnosis, or recommended treatments.