Granulomatous cheilitis

Introduction to granulomatous cheilitis Granulomatous cheilitis, also known as Michelle granulomatous cheilitis, this disease should be differentiated from lip swelling caused by odontogenic infection, cerebrovascular neuroedema, Crohn's disease, Ascher syndrome. Most of them are young or middle-aged. It may be associated with bacterial or viral infections such as streptococci, mycobacteria, and herpes simplex virus, and is related to allergic reactions and genetic factors such as cobalt, cinnamon, cocoa, and the like. basic knowledge The proportion of illness: 0.002% Susceptible people: more in young and middle-aged Mode of infection: non-infectious Complications: measles

Causes of granulomatous cheilitis

(1) Causes of the disease

Bacterial, viral infections (35%):

The pathogenic factors are unclear, and some people think that they may be infected with bacteria or viruses such as streptococci, mycobacteria, and herpes simplex virus. A lesion caused by a bacterial or viral infection.

Endocrine disorders (25%):

The vasomotor disorder regulated by the autonomic nervous system has an endocrine system that secretes various hormones and the nervous system to regulate the metabolism and physiological functions of the human body. Under normal circumstances, various hormones are balanced, such as breaking the balance for some reason (some hormones are too much or too little), which causes endocrine disorders, which will cause corresponding clinical manifestations. Endocrine disorders can occur in both men and women.

Allergic reaction (15%):

Allergic reactions to cobalt, cinnamon, cocoa, and celery oil.

Genetic factors (12%):

May be related to genetic factors and so on.

Other (10%):

There are also reports in the literature that may be related to chronic apical periodontitis and nasopharynx inflammation. Female patients may be related to the menstrual cycle.

(two) pathogenesis

It may be a delayed hypersensitivity reaction or a secondary manifestation of recurrent angioedema.

Granulomatous cheilitis prevention

1. Pay attention to rest, work and rest, and orderly life.

2. Diet should be light and nutritious. Eat more vegetables, fruits, milk, turtles and other rich in amino acids, vitamins, protein and digestible nourishing food.

3. Eat less greasy food, eat less warm food such as dog meat and mutton; eat less shellfish, bamboo shoots, glutinous rice and other allergic "hair products", eat less chemicals, preservatives, additives Drinks and snacks. Do not eat too acidic, too spicy, too salty. Avoid irritants such as tobacco and alcohol.

Granulomatous cheilitis complications Complications measles

Ulcer, dry lip, lip bleeding.

Granulomatous lipitis symptoms common symptoms progressive granulomatous ulcer necrosis granuloma crusted nodules

More common in young and middle-aged, more for the lower lip, and then the upper lip, the performance of sudden mucosal swelling, hypertrophy, rough, desquamation, dry crack, sometimes can be wet, exudate, crusting, etc., the disease can be periodic Attacks, progressive exacerbations, some cases can appear nodules in the mouth, salivary glands, etc., consciously numb, pain, discomfort.

Examination of granulomatous cheilitis

Histopathological examination: Early skin lesions showed lymphedema of the dermis with mild perivascular lymphocytic infiltration, and late or focal tuberculosis or lymphoid cells and plasma cell infiltration.

Local examination: diffuse swelling of the sudden burst of the lips, recurrent episodes, progressive exacerbations without systemic symptoms.

Diagnosis and diagnosis of granulomatous cheilitis

According to the diffuse swelling of the sudden burst of the lips, recurrent episodes, progressive exacerbation without systemic symptoms can be diagnosed.

Differential diagnosis:

Need to be differentiated from angioedema, the latter more than 1 to 2 days to fade, and no traces after disappearing, there will be no lumps left, and often accompanied by other wheals or past history of urticaria.

The disease should be differentiated from lip swelling, cerebrovascular neuroedema, Crohn's disease, Ascha syndrome caused by odontogenic infection. Odontogenic infection often has a history of field teeth; lip vascular neuropathic edema is an allergic reaction, rapid onset, lip red mucosa color is normal or reddish, has a fever, sometimes traces back to allergens; Crohn's disease in addition to oral performance The main symptoms are segmental localized enteritis, intestinal obstruction and fistula formation and digestive tract dysfunction, as well as arthritis, spondylitis, uveitis, nodular erythema and other manifestations; Ascher syndrome with eyelid relaxation and upper lip Progressive hypertrophy is characterized by infant or childhood onset, and many patients have goiter, but no abortion occurs in adolescence.

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