Sarcoma skin metastases

Introduction to sarcoma skin metastasis Sarcomas' skin metastatic sarcomas account for 3% and 2% of male and female skin metastases, respectively. Sources of cutaneous sarcoma include leiomyosarcoma, rhabdomyosarcoma, fibrosarcoma, chondroblastoma, Ewing sarcoma, osteogenic sarcoma. And undifferentiated sarcoma, distal skin metastatic sarcoma can also be derived from the dermis, subcutaneous tissue or soft tissue beneath it as epithelioid cell sarcoma and malignant fibrous histiocytoma. basic knowledge The proportion of illness: the incidence rate is about 0.001% Susceptible people: no special people Mode of infection: non-infectious Complications: liver cancer

Sarcoid skin metastasis

(1) Causes of the disease

The disease is a malignant tumor disease, the cause is not clear, and may have certain correlation with environmental factors, genetic factors, dietary factors, and mood and nutrition during pregnancy. The disease has primary tumor lesions, so the physical examination should be done to determine the location and nature of the primary tumor.

(two) pathogenesis

The pathogenesis is still unclear. Pathological examination: Skin metastatic leiomyosarcoma is a nodule composed of a fusiform cell bundle with clear or invasive boundaries located in the dermis or subcutaneous tissue. Tumor cells are eosinophilic and have varying degrees of Atypical, skin metastatic rhabdomyosarcoma, usually a poorly differentiated tumor.

Sarcoma skin metastasis prevention

1. Adjust daily life and workload, and regularly carry out activities and exercise to avoid fatigue.

Sarcoma skin metastasis complications Complications

Sarcoma is a malignant neoplastic disease. Due to the hyperplasia of the tumor tissue, tissue ischemic necrosis can be caused by insufficient blood supply. The skin metastasis of sarcoma is usually a part of metastasis. He can also metastasize the internal organs and bones to form metastatic liver cancer, as well as osteosarcoma and other diseases. The disease is extremely malignant and the treatment effect is not satisfactory.

Sarcoma skin metastasis symptoms common symptoms nodular endometriosis implanted nodular skin metastasis

Skin metastatic sarcomas occur in the head, trunk and extremities, with a firm skin color or red-purple nodules that can form ulcers and/or pain.

Sarcoid skin metastasis examination

Histopathology: Skin metastatic leiomyosarcoma is a nodule composed of a fusiform cell bundle with clear or invasive boundaries located in the dermis or subcutaneous tissue. Tumor cell cytoplasmic eosinophilic, with varying degrees of atypical, skin metastatic Rhabdomyosarcoma, usually a poorly differentiated tumor, with atypical cytoplasmic eosinophilic atypical cells and multinucleated giant cells or cells with small cytoplasm and small staining, only some tumors have long-banded eosinophils, Recognized as striated muscle cells with cytoplasmic transverse stripes, skin metastatic fibrosarcoma is arranged by spindle cell bundles into squid bones, pleomorphic cells and giant cells are few, and well differentiated tumors have more spindle cells. And collagen fibers, while poorly differentiated tumors have anaplastic cells and mitotic figures. Malignant fibrous histiocytoma has several subtypes including sessile polymorphism, xanthomatous, inflammatory, mucinous, hemangioma-like and giant Cell type.

Diagnosis and differentiation of sarcoma skin metastasis

diagnosis

According to clinical manifestations, the characteristics of skin lesions and histopathological features can be diagnosed. The following points should be noted:

1. Clinically short-term (6 to 12 months) rapid growth of tumor nodules, distributed in the vicinity of the primary tumor surgery area or the corresponding lymphatic drainage area, and its histopathological morphology is similar to the primary tumor, especially When it is characterized by multiple or multifocal tumors, it should be considered as metastatic cancer of the skin.

2. Tumor plugs are found in the skin or subcutaneous fat vessels or lymphatic vessels. The distribution configuration of the cancer is narrow and trapezoidal at the bottom, generally not connected with the epidermis, there is very little inflammatory cell infiltration around the tumor cells, and no sweat gland ductal keratin membrane Differentiation, etc., are often characteristic of metastatic skin tumors.

3. It is helpful to distinguish by means of immunohistochemical markers. For example, the tumor originated from the sweat gland-derived tumor is positive for GCDFP-15, while the tumors of the prostate and thyroid metastasized to the skin are positive for PSA and TG, respectively. In addition, metastatic skin in the umbilical cord Nodules must be excluded from endometriosis or implanted nodules, and should also be distinguished from yolk sac or urinary tract embryo residues.

Differential diagnosis

Ewing sarcoma should be differentiated from fibrosarcoma or malignant fibrous histiocytoma.

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