Malignant hemangioendothelioma

Introduction to malignant vascular endothelial cell tumor Malignantangioendothelioma (malignantangioendothelioma), also known as angiosarcoma, is a rare malignant endothelial cell tumor that occurs in the skin, soft tissues, breast, bone, liver and other internal organs. Skin angiosarcoma is the most common type of angiosarcoma. basic knowledge The proportion of illness: 0.001% Susceptible people: no special people Mode of infection: non-infectious Complications: congestive heart failure

Cause of malignant vascular endothelial cell tumor

Cause:

The pathogenesis is still unclear. Histopathology indicates that the tumor is composed of heterogeneous endothelial cells. The tumor cells are irregular, can be matched and communicate with each other to form a lumen, a cancer nest or a mass. The boundaries between tumor cells are unclear and often cluster together to form a syncytium.

Malignant vascular endothelial cell tumor prevention

Appropriate exercise, enhance physical fitness and improve your disease resistance.

Malignant vascular endothelial cell tumor complications Complications, congestive heart failure

Complications of hemangioma include ulcers, hemorrhage, infection, damage to vital organs, congestive heart failure, and limb deformities caused by skeletal muscle damage.

Malignant vascular endothelial cell tumor symptoms common symptoms internal bleeding edema edema nodules

Clinically, it can be divided into 3 types:

1. angiosarcoma of the scalp and face of elderly

The most common, more men than women, skin lesions occurred in the head and neck of the elderly, began to be a pale blue spot with unclear boundaries, may be misdiagnosed as ecchymosis, but there are red rings around the ecchymoses, satellite nodules, Intratumoral hemorrhage, as well as the tendency of spontaneous bleeding after mild traumatic lesions, is characterized by progressive asymmetry of the tumor, and develops into indurated light blue nodules and plaques. In the head and face, obvious edema can occur in the eyelids. .

2. lymphoedema angiosarcoma (angiosarcoma in lymphedema)

Angiosarcoma occurs in the chronic lymphedema, such as the upper arm after radical mastectomy, the so-called Stwart Treves syndrome, which usually occurs 11 to 12 years after surgery. It is estimated that about 0.45% of patients have onset, and the lesion is edema. One or more ecchymoses develop rapidly into pale blue to purple red nodules, which are prone to ulceration and spread to the proximal or distal end of the limb. The prognosis is generally poor, and the 5-year survival rate is 6% to 14%. The average survival rate was 19 to 31 months, and lung metastasis was a common cause of death.

3. Angiosarcoma after radiation therapy after radiotherapy

Rarely, tumors occur in areas where radiation therapy has previously been performed. For example, if radiation therapy is a benign disease, the average interval between radiation therapy and angiosarcoma is 23 years. However, if the disease is malignant, radiation therapy is performed to the blood vessels. The interphase of the tumor can be shortened by 12 years. The prognosis of this disease is poor, and the average survival time after diagnosis is 6 months to 2 years.

Examination of malignant vascular endothelial cell tumor

Histopathology: Tumor tissue varies in degree of differentiation in the same lesion, usually affecting peripheral differentiation is better, but infiltration is severe, often the center of nodules and ulcers is poorly differentiated.

In well-differentiated areas, vessels with irregularities often coincide with each other, and the lumens are arranged by endothelial cells, mostly single-layer, but some are multi-layered, carefully examined, although some endothelial cells are abnormally large and polymorphic. Sexual, but still easily misdiagnosed as non-specific granuloma, in the poorly differentiated area, the vascular lumen is arranged by completely atypical cuboidal endothelial cells, the vascular lumen can be significantly expanded, so that they have many curved sinuses, sinus endothelium Cell proliferation, like papillary protrusions, or they can form several layers, and completely fill the lumen, reticular fiber staining has a certain value in identifying malignant hemangioma, because in the area where it is difficult to see the lumen of the blood vessel, A reticular annulus can be seen around the endothelial cells, delineating the contour of the basement membrane, and even in the solid region of endothelial cell proliferation, in some tumor cells of a single endothelial cell, a dense reticular fiber network can also be displayed, immunizing Histochemical staining, vitexin 1, vimentin, laminin and other endothelial cell markers were positive, but factor 8 Off antigen positive or negative often varying degrees.

Diagnosis and diagnosis of malignant vascular endothelial cell tumor

According to the clinical classification, the characteristics of skin lesions, combined with histopathology can be diagnosed.

There are red rings around the ecchymoses, satellite nodules, intratumoral hemorrhage, and spontaneous bleeding after slight traumatic lesions.

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