Chlorpromazine poisoning

Introduction to chlorpromazine poisoning Chlorpromazine is a derivative of phenothiazine. Currently used are chlorpromazine (hibernation), acetylpromazine, promethazine, perphenazine, trifluoperazine, etc., chlorpromazine. Most of the poisoning of the class is caused by excessive drug use or a large amount of self-picked by children. basic knowledge The proportion of illness: 0.003% Susceptible people: good for children Mode of infection: non-infectious Complications: difficulty swallowing

Causes of chlorpromazine poisoning

Cause:

Excessive misuse, long-term application of larger doses during treatment, some patients with allergies to this class of drugs, can cause poisoning, because chlorpromazine is a post-synaptic dopamine receptor blocker.

Chlorpromazine poisoning prevention

1. Pay attention to the strict indications and dosages. For long-term use, attention should be paid to side effects and toxic reactions.

2. Patients with heart, liver, renal insufficiency and significant inhibition of the central nervous system should be banned or used with caution.

3. Psychiatric patients should be administered by the patient's family or medical staff according to each dose.

4. With general anesthetics (including alcohol), anticholinergic drugs (such as atropine), antipyretic analgesics, antihypertensive drugs, anti-shock drugs (such as levodopa) and other drugs must be used with caution.

5. When using insulin, hypoglycemic, sulfonylureas and other drugs, do not use chlorpromazine drugs at the same time, so as not to cause jaundice and abnormal liver function.

Complications of chlorpromazine poisoning Complications, difficulty swallowing, torticollis

Can occur extra-vertebral symptoms such as tremor muscle tonic involuntary movement, close the dysphagia, torticollis, eye rotation, etc., children with strong and not quiet, can also face facial paralysis, difficulty in pronunciation and stuttering, around the eyelids Muscle spasms, and even the angulation of the horns, a small number of eye damage caused by vision loss, and even blindness. The urinary chlorpromazine test was positive.

Symptoms of chlorpromazine poisoning Common symptoms Dizziness, swallowing difficulty, difficulty in breathing, expression, indifferent, rogue, limbs, cold, abdominal distension, abdominal pain, nausea, lethargy

When misusing a large dose, the child develops dizziness, drowsiness, apathy, weakness, sometimes causing mental disorders, gibberish; can also cause hooliganism, nausea, vomiting, abdominal pain, bloating, jaundice, hepatomegaly, etc. Acute poisoning caused by high dose often occurs palpitations, cold extremities, blood pressure, even shock, difficulty breathing, dilated pupils, coma and reflexes disappear, protein, red, white blood cells and casts can appear in urine, long-term application Dose can cause granulocyte reduction, thrombocytopenia, hemolytic anemia, etc., even aplastic anemia, occasionally due to treatment doses of jaundice, liver and lymphadenopathy, asthma, rash, purpura, neutropenia, fever, etc. And can occur extra-vertebral symptoms, such as tremor, muscle rigidity, involuntary movement, closed jaw, difficulty swallowing, torticollis, eye rotation, etc., children with tonic and can not be quiet, can also face facial nerve paralysis, pronunciation Difficulties and stuttering, muscle spasm around the eyelids, and even angulation of the horns, a small number of eye damage, leading to vision loss, even blindness, urine Oxaprozin test positive.

Chlorpromazine poisoning test

It can be used for urine chlorpromazine qualitative test, urine routine and urinary bladder, blood routine (bone marrow smear test if necessary), blood chemistry (sugar, cholesterol determination) and liver function tests.

Diagnosis and identification of chlorpromazine poisoning

History of medication, coma, respiratory depression, needle tip-like pupils sometimes need to be identified with organophosphate poisoning, carbamate poisoning.

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